Document Detail

The association between interleukin-18 and pulmonary sarcoidosis: a meta-analysis.
MedLine Citation:
PMID:  20653400     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the association between interleukin-18 (IL-18) and pulmonary sarcoidosis.
MATERIALS AND METHODS: The Medline, Embase and Cochrane databases were searched to identify relevant studies. Studies were eligible for inclusion if they enrolled newly-diagnosed, untreated pulmonary sarcoidosis patients with IL-18 measurement in bronchoalveolar lavage fluid (BALF) or blood. A randomized effects model was used to pool six relevant studies.
RESULTS: The IL-18 levels of BALF and blood in patients with pulmonary sarcoidosis were significantly higher than those in control subjects (p = 0.0001, p = 0.04, respectively).
CONCLUSION: This meta-analysis has observed some evidence showing that the published results from these studies indicated the statistically significant association between IL-18 and pulmonary sarcoidosis.
Ding-Hua Liu; Yun-Tai Yao; Wei Cui; Ke Chen
Publication Detail:
Type:  Journal Article; Meta-Analysis    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  70     ISSN:  1502-7686     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-16     Completed Date:  2011-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  England    
Other Details:
Languages:  eng     Pagination:  428-32     Citation Subset:  IM    
Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
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MeSH Terms
Biological Markers / blood
Bronchoalveolar Lavage Fluid / chemistry
Databases, Bibliographic
Databases, Factual
Interleukin-18 / blood*
Sarcoidosis, Pulmonary / blood*,  pathology
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-18

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