Document Detail

The association between inherited thrombophilias and pregnancy-related hypertension recurrence.
MedLine Citation:
PMID:  21072525     Owner:  NLM     Status:  In-Data-Review    
PURPOSE: The aim of this study was to determine the association between inherited thrombophilias and pregnancy-related hypertension recurrence.
METHODS: In this case-control study, blood samples were obtained from patients who had at least two pregnancies complicated with pregnancy-related hypertension (n = 41) and healthy, normotensive pregnancies delivered without any complication (n = 38). Following the DNA extraction, samples were tested for factor V Leiden, prothrombin G20210A and homozygous methylene tetrahydrofolate reductase (MTHFR) C677T mutations using reverse hybridization method.
RESULTS: Common inherited thrombophilias were present in 26.8% of women with recurrent pregnancy-related hypertension group and 23.7% of control subjects (odds ratio 1.1; 95% confidence interval, 0.6-1.9). No significant difference was observed between two groups in terms of factor V Leiden, prothrombin G20210A and MTHFR C677T mutations.
CONCLUSION: Our data suggest that factor V Leiden, prothrombin G20210A and MTHFR C677T mutations are not associated with pregnancy-related hypertension recurrence.
Inanc Mendilcioglu; Turker Bilgen; Yunus Arikan; Ibrahim Keser; Mehmet Simsek; Aysen Timuragaoglu
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Publication Detail:
Type:  Journal Article     Date:  2010-11-12
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  284     ISSN:  1432-0711     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  837-41     Citation Subset:  IM    
Department of Obstetrics and Gynecology, School of Medicine, Akdeniz University, Dumlupinar Boulevard, 07070, Antalya, Turkey,
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