| The association between inherited thrombophilias and pregnancy-related hypertension recurrence. | |
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MedLine Citation:
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PMID: 21072525 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: The aim of this study was to determine the association between inherited thrombophilias and pregnancy-related hypertension recurrence. METHODS: In this case-control study, blood samples were obtained from patients who had at least two pregnancies complicated with pregnancy-related hypertension (n = 41) and healthy, normotensive pregnancies delivered without any complication (n = 38). Following the DNA extraction, samples were tested for factor V Leiden, prothrombin G20210A and homozygous methylene tetrahydrofolate reductase (MTHFR) C677T mutations using reverse hybridization method. RESULTS: Common inherited thrombophilias were present in 26.8% of women with recurrent pregnancy-related hypertension group and 23.7% of control subjects (odds ratio 1.1; 95% confidence interval, 0.6-1.9). No significant difference was observed between two groups in terms of factor V Leiden, prothrombin G20210A and MTHFR C677T mutations. CONCLUSION: Our data suggest that factor V Leiden, prothrombin G20210A and MTHFR C677T mutations are not associated with pregnancy-related hypertension recurrence. |
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Authors:
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Inanc Mendilcioglu; Turker Bilgen; Yunus Arikan; Ibrahim Keser; Mehmet Simsek; Aysen Timuragaoglu |
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Publication Detail:
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Type: Journal Article Date: 2010-11-12 |
Journal Detail:
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Title: Archives of gynecology and obstetrics Volume: 284 ISSN: 1432-0711 ISO Abbreviation: Arch. Gynecol. Obstet. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710213 Medline TA: Arch Gynecol Obstet Country: Germany |
Other Details:
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Languages: eng Pagination: 837-41 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, School of Medicine, Akdeniz University, Dumlupinar Boulevard, 07070, Antalya, Turkey, imendilcioglu@yahoo.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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