Document Detail

An association between increased porphyrin precursors and onset of abdominal symptoms in lead poisoning.
MedLine Citation:
PMID:  6719506     Owner:  NLM     Status:  MEDLINE    
To examine a potential role of porphyrinopathy induced by lead (Pb) exposure in the pathogenesis of constipation in Pb poisoning, a Pb-intoxicated worker was subjected to the serial determinations for various biochemical indicators of Pb exposure in relation to the onset of constipation. The results have shown that the onset of constipation parallels a rapid rise in either urinary delta-aminolevulinic acid (ALA) or coproporphyrin (CP), or both. The present evidence is not yet conclusive as to the involvement of porphyrinopathic mechanism in the development of constipation in Pb intoxication.
Y Okamoto; M Kawai
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Toxicology letters     Volume:  21     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  1984 May 
Date Detail:
Created Date:  1984-06-11     Completed Date:  1984-06-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  219-23     Citation Subset:  IM    
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MeSH Terms
Aminolevulinic Acid / urine
Constipation / chemically induced*,  metabolism
Lead Poisoning / complications,  metabolism*
Middle Aged
Occupational Diseases / metabolism
Porphyrins / metabolism*
Reg. No./Substance:
0/Porphyrins; 106-60-5/Aminolevulinic Acid

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