Document Detail

The association between an increased level of gamma-glutamyl transferase and systolic blood pressure in diabetic subjects.
MedLine Citation:
PMID:  18441507     Owner:  NLM     Status:  MEDLINE    
Gamma-glutamyl transferase (GGT) is an enzyme present in serum and on most cell surfaces and serves as an oxidative stress marker. Although serum GGT is associated with hypertension development, little data are available on the associations between GGT and hypertension among populations with diabetes mellitus (DM). Our aim was to investigate the potential association between the changes in systolic or diastolic blood pressure (SBP/DBP) and the GGT level in type 2 DM subjects, in comparison with non-DM subjects. In 179 non-DM and 177 DM subjects, SBP/DBP, body mass index (BMI), fasting plasma glucose, serum asparate aminotransferase, alanine aminotransferase and GGT were measured at the baseline and after a 1-year period. Between these 2-measurement points, in non-DM subjects, SBP and DBP levels were significantly increased, while GGT tended to increase. In contrast, in DM subjects, the mean levels of SBP, DBP and GGT remained unchanged. Multivariate analysis revealed that in non-DM subjects the degree of increase in SBP was significantly and positively correlated to that of GGT (beta = 0.165), along with age and BMI. Likewise, the increase in DBP was correlated to that of GGT in non-DM subjects (beta = 0.170). In contrast, in DM subjects, the degree of increase in SBP was significantly correlated to that of only GGT (beta = 0.166). These results suggest that the presence of DM may attenuate the effects of GGT on DBP.
Kazuhiko Kotani; Hisashi Shimohiro; Seiji Adachi; Naoki Sakane
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  214     ISSN:  1349-3329     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-28     Completed Date:  2008-05-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  321-5     Citation Subset:  IM    
Division of Health Administration and Promotion, Faculty of Medicine, Tottori University, Yonago, Japan.
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MeSH Terms
Alanine Transaminase / blood
Aspartate Aminotransferases / blood
Blood Glucose
Blood Pressure / physiology*
Body Mass Index
Diabetes Mellitus, Type 2 / metabolism*
Diabetic Angiopathies / metabolism*
Hypertension / metabolism*
Middle Aged
Oxidative Stress / physiology
gamma-Glutamyltransferase / blood*
Reg. No./Substance:
0/Blood Glucose; EC; EC Aminotransferases; EC Transaminase

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