Document Detail

The association between hypertensive disorders of pregnancy and abnormal second-trimester maternal serum levels of hCG and alpha-fetoprotein.
MedLine Citation:
PMID:  9166297     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the association between hypertensive disorders of pregnancy and second-trimester maternal serum alpha-fetoprotein (MSAFP) and hCG levels. METHODS: The proportions of abnormal second-trimester MSAFP and hCG levels in the serum samples from 65 women with true pregnancy-induced hypertension or preeclampsia (cases) were compared to the proportions of abnormal levels in all 1943 women without this disorder in the same cohort in a hospital setting. Maternal serum alpha-fetoprotein and hCG levels of the 65 cases also were compared to those of 325 completely uncomplicated matched control pregnancies, selected from the same cohort. Fisher exact test and Student t test were used for statistical analysis and P < .05 was considered statistically significant. RESULTS: An MSAFP level at least 2.5 multiples of the median (MoM) was found in two of 65 cases (3.1%) and in 27 of 1943 women (1.4%) in the rest of the cohort, a nonsignificant difference (relative risk [RR] = 2.2; P = .24). The statistical power to identify a significant difference for this RR was .27. An hCG level of at least 2.5 MoM was found in six cases (9.2%) and in 89 (4.6%) of women in the rest of the cohort, also a nonsignificant difference (RR = 2.0; P = .12). The statistical power to identify a significant difference for this RR was .38. The mean (+/-standard deviation) logarithms of the MSAFP and hCG MoMs in the 65 cases (0.039 +/- 0.191 and 0.048 +/- 0.265, respectively) were not significantly different from those in the 325 matched controls (0.006 +/- 0.148 and -0.010 +/- 0.244, respectively; P = .12 and .08, respectively). CONCLUSION: Although a weak association cannot be excluded, this study found no clinically important increase in risk of developing subsequent hypertensive disorders of pregnancy among women with abnormal second-trimester levels of MSAFP or hCG.
L P Morssink; M P Heringa; J R Beekhuis; B T De Wolf; A Mantingh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  89     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-06-24     Completed Date:  1997-06-24     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  666-70     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynaecology, University Hospital, Groningen, The Netherlands.
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MeSH Terms
Case-Control Studies
Chorionic Gonadotropin / blood*
Cohort Studies
Hypertension / blood*
Pre-Eclampsia / blood*
Pregnancy Complications, Cardiovascular / blood*
Pregnancy Outcome
Pregnancy Trimester, Second
Risk Factors
alpha-Fetoproteins / metabolism*
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/alpha-Fetoproteins
Comment In:
Obstet Gynecol. 1997 Sep;90(3):480-1   [PMID:  9277668 ]

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