Document Detail

The association between homocysteine in the follicular fluid with embryo quality and pregnancy rate in assisted reproductive techniques.
MedLine Citation:
PMID:  22271234     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the association between follicular fluid homocysteine levels and embryo quality and pregnancy rates in patients undergoing assisted reproduction.
METHODS: Fifty infertile women who were admitted to our clinic were enrolled in the study. Ovulation induction was performed by using GnRH agonist and gonadotropins. For each patient, homocysteine level in the follicular fluid was measured by using nephelometric method after the oocyte pick-up. The association between the homocysteine concentration in the follicular fluid and the oocyte-embryo quality, pregnancy rates and hormone levels were investigated.
RESULTS: Mean ± SD Hcy was 9.6 ± 2.02 μmol/L and 14.9 ± 2.93 μmol/L in pregnant and non-pregnant women, respectively (p < 0.0001). There were no statistically significant differences between pregnant and non-pregnant women in mean age, duration of infertility, body mass index, the oocyte-embryo quality parameters, and hormone levels. Homocystein did not have any correlation with M2, late M2, and total number of oocytes, number of fertilized oocytes and transferred embryos, and embryo quality grade. Area under curve (AUC) of hcy for prediction of pregnancy failure was 0.922 (p = 0.0001, 95% Confidence interval 0.85-0.99). A threshold of 11.9 μmol/L of hcy had a sensitivity of 82%, specificity of 100%, positive predictive value of 100% and negative predictive value of 91.6% for prediction of pregnancy failure. The subgroup analysis in male factor infertility group (n = 28), showed that mean homocystein was 9.9 ± 2.44 μmol/L and 14.1 ± 2.72 μmol/L in pregnant and non-pregnant women, respectively (p = 0.002).
CONCLUSION: Low follicular fluid homocysteine level is associated with a better chance of clinical pregnancy.
Pelin Ocal; Bilge Ersoylu; Ismail Cepni; Onur Guralp; Nil Atakul; Tulay Irez; Mehmet Idil
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Publication Detail:
Type:  Journal Article     Date:  2012-01-21
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  29     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-22     Completed Date:  2012-09-24     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  299-304     Citation Subset:  IM    
Cerrahpasa Medical Faculty, Obstetrics and Gynecology, Reproductive Endocrinology, Istanbul University, Istanbul, Turkey.
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MeSH Terms
Embryo Transfer / methods
Estradiol / metabolism
Follicular Fluid / metabolism*
Homocysteine / metabolism*
Infertility, Female
Oocytes / metabolism*,  physiology*
Pregnancy Rate
Reproductive Techniques, Assisted*
Sperm Injections, Intracytoplasmic / methods
Reg. No./Substance:
454-28-4/Homocysteine; 50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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