Document Detail


The association between high-activity COMT allele and alcoholism.
MedLine Citation:
PMID:  16648777     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The catechol-O-methyltransferase (COMT) is an enzyme involved in the metabolism of dopamine, adrenaline and noradrenaline. The Val158Met polymorphism of the COMT gene has been previously associated with a variability of the COMT activity, and alcoholism. The aim of the present association study was to examine the relationship between the Val158Met polymorphism of the COMT gene and dispositions to alcoholism. METHODS: In our case control study we analyzed DNA samples from 799 subjects in total (279 male alcoholics and 120 female alcoholics, 151 male controls and 249 female controls). The restriction analysis for the detection of the Val158Met polymorphism was used. RESULTS: We found a relationship between the Val158Met polymorphism of the COMT gene and alcoholism in male subjects. We found the significant difference between male alcoholics and male controls in allele and genotype frequencies (p<0,007; and p<0,04 respectively). CONCLUSIONS: Our study confirmed the relationship between the COMT polymorphism and alcoholism in the Czech male population.
Authors:
Omar Serý; William Didden; Vladimír Mikes; Renáta Pitelová; Vladimír Znojil; Petr Zvolský
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuro endocrinology letters     Volume:  27     ISSN:  0172-780X     ISO Abbreviation:  Neuro Endocrinol. Lett.     Publication Date:    2006 Feb-Apr
Date Detail:
Created Date:  2006-12-13     Completed Date:  2007-01-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008373     Medline TA:  Neuro Endocrinol Lett     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  231-5     Citation Subset:  IM    
Affiliation:
Laboratory of neurobiology and molecular psychiatry, Department of Biochemistry, Masaryk University, Faculty of Science, Brno, Czech Republic. omarsery@sci.muni.cz
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcoholism / enzymology,  genetics*
Alleles
Amino Acid Substitution
Catechol O-Methyltransferase / genetics*
DNA / genetics
Female
Gene Frequency
Humans
Japan / epidemiology
Male
Middle Aged
Mutation / physiology
Polymorphism, Genetic / genetics
Polymorphism, Restriction Fragment Length
Sex Characteristics
Chemical
Reg. No./Substance:
9007-49-2/DNA; EC 2.1.1.6/Catechol O-Methyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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