Document Detail


The association between hereditary thrombophilias and pregnancy loss.
MedLine Citation:
PMID:  16154846     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The correlation between hereditary thrombophilia and fetal loss is supported by several observations. In murine models, the protein C system has been shown to be essential for the maintenance of pregnancy, as it indirectly acts as a growth factor for trophoblast cells and protects them from apoptosis. In humans, it has been shown that the placenta replaces the yolk sac as an essential source of blood supply to the embryo during the 8th and 9th weeks of gestation. Furthermore, meta-analysis of epidemiological data demonstrates a correlation between thrombophilic polymorphisms such as factor V Leiden and prothrombin 20210G-->A and isolated or recurrent fetal losses. Finally, therapeutic non-controlled trials indicate the benefits and safety of low-molecular weight heparins as secondary prophylaxis. However, it is still necessary to further clarify the association between thrombophilia and fetal loss, especially during a first pregnancy, with regard to the type of pregnancy loss and with respect to other related factors.
Authors:
Géraldine Lissalde-Lavigne; Eva Cochery-Nouvellon; Eric Mercier; Isabelle Quéré; Michel Dauzat; Pierre Marès; Jean-Christophe Gris
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Haematologica     Volume:  90     ISSN:  1592-8721     ISO Abbreviation:  Haematologica     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-12     Completed Date:  2006-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417435     Medline TA:  Haematologica     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  1223-30     Citation Subset:  IM    
Affiliation:
Laboratory of Hematology, University Hospital Nîmes, France.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / epidemiology,  etiology*,  genetics*
Animals
Female
Humans
Pregnancy
Thrombophilia / complications*,  epidemiology,  genetics*

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