Document Detail

The association between follicular size on human chorionic gonadotropin day and pregnancy rate in clomiphene citrate treated polycystic ovary syndrome patients.
MedLine Citation:
PMID:  20218821     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine leading follicle size on human chorionic gonadotropin (hCG) day and pregnancy rate in anovulatory polycystic ovary syndrome (PCOS) patients treated with clomiphene citrate (CC). DESIGN: Retrospective cohort study. SETTING: Fertility clinics in women's health centers. PATIENTS: Data on 291 infertile women with PCOS and irregular cycles who underwent 685 CC treatment cycles were used. Only cycles with one or two follicles >14 mm were included. hCG was administered once the leading follicle reached the size of 17-24 mm. MAIN OUTCOME MEASURE(S): Pregnancy rates in relation to leading follicle size. RESULTS: Mono/bi-follicular response was observed in 418 cycles. Pregnancy rates were highest (13.6-18.6%) when hCG was administered in the presence of an 18-22 mm follicle, lowest with 17 mm, 23 mm and 24 mm (8.8%, 8.8% and 5.7%, respectively). No differences were observed in pregnancy rates between mono and bi-follicular cycles. CONCLUSIONS: In CC treatment, hCG should be administered when follicular size is at the range of 18-22 mm.
Jacob Farhi; Raoul Orvieto; Oz Gavish; Roy Homburg
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  26     ISSN:  1473-0766     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  546-8     Citation Subset:  IM    
Fertility Clinics, Ashdod and Holon Women's Health Centers, Clalit Medical Services, Rabin Medical Center, Petach Tikva, Israel.
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MeSH Terms
Chi-Square Distribution
Chorionic Gonadotropin / therapeutic use*
Clomiphene / therapeutic use*
Fertility Agents, Female / therapeutic use
Ovarian Follicle / physiology*
Polycystic Ovary Syndrome / drug therapy*
Pregnancy Rate*
Retrospective Studies
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Fertility Agents, Female; 911-45-5/Clomiphene

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