| The association between follicular size on human chorionic gonadotropin day and pregnancy rate in clomiphene citrate treated polycystic ovary syndrome patients. | |
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MedLine Citation:
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PMID: 20218821 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine leading follicle size on human chorionic gonadotropin (hCG) day and pregnancy rate in anovulatory polycystic ovary syndrome (PCOS) patients treated with clomiphene citrate (CC). DESIGN: Retrospective cohort study. SETTING: Fertility clinics in women's health centers. PATIENTS: Data on 291 infertile women with PCOS and irregular cycles who underwent 685 CC treatment cycles were used. Only cycles with one or two follicles >14 mm were included. hCG was administered once the leading follicle reached the size of 17-24 mm. MAIN OUTCOME MEASURE(S): Pregnancy rates in relation to leading follicle size. RESULTS: Mono/bi-follicular response was observed in 418 cycles. Pregnancy rates were highest (13.6-18.6%) when hCG was administered in the presence of an 18-22 mm follicle, lowest with 17 mm, 23 mm and 24 mm (8.8%, 8.8% and 5.7%, respectively). No differences were observed in pregnancy rates between mono and bi-follicular cycles. CONCLUSIONS: In CC treatment, hCG should be administered when follicular size is at the range of 18-22 mm. |
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Authors:
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Jacob Farhi; Raoul Orvieto; Oz Gavish; Roy Homburg |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Volume: 26 ISSN: 1473-0766 ISO Abbreviation: Gynecol. Endocrinol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-09-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8807913 Medline TA: Gynecol Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 546-8 Citation Subset: IM |
Affiliation:
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Fertility Clinics, Ashdod and Holon Women's Health Centers, Clalit Medical Services, Rabin Medical Center, Petach Tikva, Israel. j_farhi@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chi-Square Distribution Chorionic Gonadotropin / therapeutic use* Clomiphene / therapeutic use* Female Fertility Agents, Female / therapeutic use Humans Ovarian Follicle / physiology* Polycystic Ovary Syndrome / drug therapy* Pregnancy Pregnancy Rate* Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/Fertility Agents, Female; 911-45-5/Clomiphene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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