| The association between early membrane rupture, latency, clinical chorioamnionitis, neonatal infection, and adverse perinatal outcomes in twin pregnancies complicated by preterm prelabour rupture of membranes. | |
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MedLine Citation:
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PMID: 14511428 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to evaluate associations between adverse outcomes in twin pregnancies and preterm prelabour rupture of membranes (PPROM). A chart review of 246 consecutive twin pregnancies with confirmed PPROM was conducted. Regression analysis (beta [natural log of the odds ratio] and odds ratio [OR]) was performed to identify independent predictors. Two hundred and forty-six twin pregnancies, 492 liveborns, and 20 neonatal deaths. Mean (SD) PPROM gestational age (GA): 31.3 (3.8) wk; delivery GA: 32.0 (3.3) wk. PPROM < 30 wk was associated with increased parity (OR: 2.66), and log (admission leukocyte count) (OR: 9.99). Shortened latency was associated with PPROM GA (beta = -0.17) and chorioamnionitis (beta = 0.95). Neonatal sepsis was predicted by lower delivery GA (OR: 2.04). Adverse perinatal outcomes were protected against by older GA at PPROM (OR 0.53) and shortened latency (OR 0.73). It was concluded that increased leukocytosis and parity implies an infectious aetiology in earlier PPROM. Increased risk for neonatal sepsis at earlier delivery GA is consistent with gestation-dependent fetal immunocompetence. Early PPROM and long latencies were associated with increased adverse perinatal outcomes. |
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Authors:
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Peter von Dadelszen; Sari Kives; Marie-France Delisle; R Douglas Wilson; Ruth Joy; Laurie Ainsworth; Lamya Al Kharusi; Marilynne Oskamp; Jon F R Barrett; Greg Ryan; Dan Farine; P Gareth R Seaward |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Twin Study |
Journal Detail:
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Title: Twin research : the official journal of the International Society for Twin Studies Volume: 6 ISSN: 1369-0523 ISO Abbreviation: Twin Res Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-09-26 Completed Date: 2005-01-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9815819 Medline TA: Twin Res Country: Australia |
Other Details:
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Languages: eng Pagination: 257-62 Citation Subset: IM |
Affiliation:
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Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada. pvd@cw.bc.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chorioamnionitis / complications* Diseases in Twins / congenital* Female Fetal Membranes, Premature Rupture / complications* Humans Infant, Newborn Obstetric Labor, Premature / complications* Pregnancy Pregnancy Complications* Pregnancy Outcome Regression Analysis Retrospective Studies Sepsis / complications, congenital* Twins* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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