| The association between eNOS intron 4 VNTR polymorphism and delayed graft function of kidney allografts. | |
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MedLine Citation:
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PMID: 20047617 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Nitric oxide (NO) is a multifunctional agent which serves as a key signaling molecule in physiological processes such as host defense, neuronal communication, and the regulation of vascular tone. Different polymorphic variations have been identified in the human NOS3 (eNOS) gene.The aim of the present study was to examine the association between polymorphisms of the NOS3 gene (G894T substitution within exon 7 and intron 4 VNTR polymorphism) and the development of delayed graft function as well as acute and chronic rejection.One hundred eighty-seven recipients of first renal transplants were included in the study. There were no significant associations between these polymorphisms and acute and chronic kidney allograft rejection. The intron 4 polymorphism was associated with delayed graft function after transplantation. The results of this study suggest that patients with the a allele of the eNOS intron 4 VNTR polymorphism may be predisposed to delayed graft function. |
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Authors:
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Grażyna Dutkiewicz; Leszek Domanski; Agnieszka Binczak-Kuleta; Andrzej Pawlik; Krzysztof Safranow; Andrzej Ciechanowicz; Violetta Dziedziejko; Kazimierz Ciechanowski |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical transplantation Volume: 24 ISSN: 1399-0012 ISO Abbreviation: Clin Transplant Publication Date: 2010 Sep-Oct |
Date Detail:
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Created Date: 2010-11-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710240 Medline TA: Clin Transplant Country: Denmark |
Other Details:
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Languages: eng Pagination: E130-6 Citation Subset: IM |
Copyright Information:
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© 2009 John Wiley & Sons A/S. |
Affiliation:
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Department of Nephrology, Transplantology, and Internal Medicine, Pomeranian Medical University, Szczecin, Poland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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