Document Detail


The association between cord hormones and transient tachypnea of newborn in late preterm and term neonates who were delivered by cesarean section.
MedLine Citation:
PMID:  23311764     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective: Failure of adequate and timely clearance of fetal lung fluid has been implicated in transient tachypnea of the newborn (TTN). There has been lack of human data on the association between endocrinological adaptation and fetal lung fluid clearance. Although TTN development in term or late preterm newborns delivered by cesarean section (CS) is well known whether stress hormones levels at birth contribute to it or not is not known. The aim of the study was to assess the possible association between low adrenocorticothrophic hormone (ACTH), cortisol and free triiodothyronin (fT3) levels at birth and TTN in late preterm and term infants. Study design: We compared cord blood concentrations of epinephrine, cortisol, ACTH, freeT4, freeT3 and TSH in two groups of term and late pretrem infants born by ceserean section: those who developed transient tachypnea of the newborn (TTN) and a comparison group without respiratory distress. Results: While there were no significant demographic differences between patient and control groups, cord ACTH, cortisol and fT3 were significantly lower and epinephrine was higher in infants developing TTN (p<0.05). Conclusions: Lower cord levels of cortisol, ACTH and fT3 in patients with TTN may indicate the possible relation of these hormones in fetal lung fluid clearance and postnatal pulmonary adaptation through their modulatory effect on ENaC and Na-K-ATPase.
Authors:
Begum Atasay; Huseyin Ergun; Emel Okulu; Ilke Mungan Akın; Saadet Arsan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-13
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Neonatology, Professor of Pediatrics, Ankara University, Ankara, TURKEY.
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