Document Detail

The association between concomitant use of serotonergic antidepressants and lithium-induced polyuria. A multicenter medical chart review study.
MedLine Citation:
PMID:  18651340     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A previous study aimed at revealing the prevalence and determinants of lithium induced polyuria suggested an increased risk of polyuria (urine volume > or =3 L/24 h) in those using serotonergic antidepressants next to lithium. OBJECTIVE: The objective of our study was to re-evaluate this secondary finding in another study population. METHODS: We performed a multicenter medical chart review study in patients using lithium in whom a 24-hour urine volume had been determined. RESULTS: We included 116 patients, twelve (26%)of the 46 patients with polyuria used serotonergic antidepressants compared to ten (14%) of the 70 patients without polyuria. We found an increased risk of polyuria in lithium users concurrently using serotonergic antidepressants (oddsratio 2.86; 95% confidence interval 1.00-8.21), adjusted for age, gender, use of antiepileptics and thyreomimetics. CONCLUSION: Our results confirm the previous secondary finding of an increased risk of polyuria in patients using serotonergic antidepressants next to lithium. Physicians should take this into account when evaluating polyuria in patients using lithium and when choosing an antidepressant in patients using lithium.
I Wilting; A C G Egberts; K L L Movig; J H M van Laarhoven; E R Heerdink; W A Nolen
Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Pharmacopsychiatry     Volume:  41     ISSN:  0176-3679     ISO Abbreviation:  Pharmacopsychiatry     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-24     Completed Date:  2008-11-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8402938     Medline TA:  Pharmacopsychiatry     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  129-33     Citation Subset:  IM    
Utrecht University, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Division of Pharmacoepidemiology & Pharmacotherapy, Utrecht, The Netherlands.
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MeSH Terms
Antidepressive Agents / adverse effects*
Cross-Sectional Studies
Depressive Disorder / drug therapy
Lithium Chloride / adverse effects*
Logistic Models
Middle Aged
Odds Ratio
Polyuria / chemically induced*,  epidemiology
Treatment Outcome
Reg. No./Substance:
0/Antidepressive Agents; 7447-41-8/Lithium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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