| The association between concomitant use of serotonergic antidepressants and lithium-induced polyuria. A multicenter medical chart review study. | |
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MedLine Citation:
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PMID: 18651340 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A previous study aimed at revealing the prevalence and determinants of lithium induced polyuria suggested an increased risk of polyuria (urine volume > or =3 L/24 h) in those using serotonergic antidepressants next to lithium. OBJECTIVE: The objective of our study was to re-evaluate this secondary finding in another study population. METHODS: We performed a multicenter medical chart review study in patients using lithium in whom a 24-hour urine volume had been determined. RESULTS: We included 116 patients, twelve (26%)of the 46 patients with polyuria used serotonergic antidepressants compared to ten (14%) of the 70 patients without polyuria. We found an increased risk of polyuria in lithium users concurrently using serotonergic antidepressants (oddsratio 2.86; 95% confidence interval 1.00-8.21), adjusted for age, gender, use of antiepileptics and thyreomimetics. CONCLUSION: Our results confirm the previous secondary finding of an increased risk of polyuria in patients using serotonergic antidepressants next to lithium. Physicians should take this into account when evaluating polyuria in patients using lithium and when choosing an antidepressant in patients using lithium. |
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Authors:
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I Wilting; A C G Egberts; K L L Movig; J H M van Laarhoven; E R Heerdink; W A Nolen |
Publication Detail:
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Type: Journal Article; Multicenter Study |
Journal Detail:
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Title: Pharmacopsychiatry Volume: 41 ISSN: 0176-3679 ISO Abbreviation: Pharmacopsychiatry Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-24 Completed Date: 2008-11-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8402938 Medline TA: Pharmacopsychiatry Country: Germany |
Other Details:
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Languages: eng Pagination: 129-33 Citation Subset: IM |
Affiliation:
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Utrecht University, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Division of Pharmacoepidemiology & Pharmacotherapy, Utrecht, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antidepressive Agents / adverse effects* Association Cross-Sectional Studies Depressive Disorder / drug therapy Female Humans Lithium Chloride / adverse effects* Logistic Models Male Middle Aged Odds Ratio Polyuria / chemically induced*, epidemiology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents; 7447-41-8/Lithium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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