Document Detail

The association between cognitive impairment and quality of life in patients with early multiple sclerosis.
MedLine Citation:
PMID:  19944429     Owner:  NLM     Status:  MEDLINE    
Cognitive deficits are common in patients with multiple sclerosis (MS) and may be observed early in the course of the disease. Current knowledge about the association between cognitive impairment and health-related quality of life (HQOL) in patients with early MS is limited. We used a well-established battery of cognitive tests and standardized HQOL measures to examine the associations between overall and domain-specific cognitive performance and quality of life in patients with early MS. Ninety-two patients with CIS or MS diagnosed in the previous three years participating in the CLIMB Natural History Study underwent a neurologic examination, neuropsychological evaluation and quality of life assessment. Associations between cognitive scores and HQOL measures were examined. There were no differences between cognitively impaired versus unimpaired subjects on any of the HQOL measures. After controlling for depression, scores on tests of information processing speed were significantly associated with several measures of HQOL including physical well-being, fatigue, and social support. In all cases, correlations between HQOL and cognitive measures were mild. These findings were observed in patients with limited cognitive impairment and minimal physical disability. Our results suggest that cognitive remediation programs aimed at improving cognitive skills may also improve quality of life for patients with early MS.
Bonnie I Glanz; Brian C Healy; David J Rintell; Sharon K Jaffin; Rohit Bakshi; Howard L Weiner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-26
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  290     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-05-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  75-9     Citation Subset:  IM    
Copyright Information:
Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
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MeSH Terms
Adaptation, Psychological*
Cognition / physiology
Cognition Disorders / diagnosis*,  etiology*,  therapy
Cognitive Therapy
Depressive Disorder / complications,  diagnosis,  psychology
Disability Evaluation
Disease Progression
Fatigue / etiology,  psychology
Health Status
Health Surveys
Middle Aged
Multiple Sclerosis / complications*,  physiopathology,  psychology*
Neuropsychological Tests
Quality of Life / psychology*
Severity of Illness Index
Social Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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