Document Detail

The association between chlamydial-specific IgG and IgA antibodies and pregnancy outcome in an in vitro fertilization program.
MedLine Citation:
PMID:  2614217     Owner:  NLM     Status:  MEDLINE    
Chlamydial-specific IgG and IgA antibodies were determined by a single serovar (L2) immunoperoxidase assay (IPA) in the serum of all patients that have conceived in an in vitro fertilization and embryo transfer (IVF & ET) program (n = 106) and in a group of patients that went through the program at the same period of time and did not conceive (n = 94). The prevalence rate of elevated IPA IgG (titers greater than or equal to 1:128) and IPA IgA (titers greater than or equal to 1:16) specific to chlamydiae was significantly higher (P less than 0.001) in the IVF & ET pregnancy loss and nonconception groups ("failures") versus the IVF & ET term pregnancy group ("successes") (74 vs 47%, odds ratio = 4.1, and 34 vs 14%, odds ratio = 4.3, respectively). Stepwise discriminant analysis revealed that elevated specific chlamydial IgG had the greatest effect on the variance between successes and failures in this study group. Our study indicates the possible role of past or chronic active chlamydiae infection on the "take-home baby rate" in an IVF & ET program.
E Lunenfeld; B S Shapiro; B Sarov; I Sarov; V Insler; A H Decherney
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of in vitro fertilization and embryo transfer : IVF     Volume:  6     ISSN:  0740-7769     ISO Abbreviation:  J In Vitro Fert Embryo Transf     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1990-03-13     Completed Date:  1990-03-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8412594     Medline TA:  J In Vitro Fert Embryo Transf     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  222-7     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Soroka Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
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MeSH Terms
Antibodies, Bacterial / analysis*
Case-Control Studies
Chlamydia / immunology*
Chlamydia Infections / complications,  epidemiology*,  immunology
Discriminant Analysis
Fertilization in Vitro*
Immunoglobulin A / analysis
Immunoglobulin G / analysis
Infertility, Female / etiology
Pregnancy Complications, Infectious*
Pregnancy Outcome / epidemiology*
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Immunoglobulin A; 0/Immunoglobulin G

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