| The association between cadmium, lead and mercury blood levels and reproductive hormones among healthy, premenopausal women. | |
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MedLine Citation:
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PMID: 21778284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Cadmium, lead and mercury have been identified in human follicular fluid and ovarian tissue, and have been associated with adverse reproductive outcomes in epidemiologic studies; however, few studies have examined the relationship between blood metal levels and reproductive hormones. METHODS: Among 252 premenopausal women aged 18-44 years, we examined the association between blood metal levels (cadmium, lead and mercury), cycle length, and reproductive hormones [FSH, LH, estradiol (E(2)) and progesterone] measured at clinically relevant time points in the menstrual cycle. The association between metal levels (continuous) and hormone levels was assessed using linear regression with hormone levels (natural) log transformed and the results interpreted as the percentage difference in hormone level per unit increase in metal level. RESULTS: Median (interquartile range) cadmium, lead and mercury levels were 0.30 µg/l (0.19, 0.43), 0.87 µg/dl (0.68, 1.20) and 1.10 µg/l (0.58, 2.10), respectively. Each 1 µg/l increase in cadmium levels was associated with a 21% [95% confidence interval (CI): -2.9, 49.9] increase in early follicular phase E(2) levels after adjusting for age, race/ethnicity, lead and mercury. This association decreased when restricted to never smokers (10%; 95% CI: -19.5, 51.3). Cadmium was also associated with a non-significant 9% (95% CI: -0.2, 19.9), or 2.7 day, increase in cycle length among never smokers. No associations were observed between lead or mercury and the outcomes in adjusted analyses. CONCLUSIONS: Further evaluation of the association between cadmium, E(2) and cycle length is warranted, taking into consideration cigarette smoke and its multiple components. |
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Authors:
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L W Jackson; P P Howards; J Wactawski-Wende; E F Schisterman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural Date: 2011-07-21 |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 26 ISSN: 1460-2350 ISO Abbreviation: Hum. Reprod. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-16 Completed Date: 2012-03-25 Revised Date: 2013-02-08 |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: England |
Other Details:
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Languages: eng Pagination: 2887-95 Citation Subset: IM |
Affiliation:
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Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH 44106-4945, USA. leila.jackson@case.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Cadmium / blood* Estradiol / blood Female Follicle Stimulating Hormone / blood Gene Expression Regulation / drug effects Humans Lead / blood* Luteinizing Hormone / blood Menstrual Cycle Mercury / blood* Models, Statistical Progesterone / blood Regression Analysis Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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50-28-2/Estradiol; 57-83-0/Progesterone; 7439-92-1/Lead; 7439-97-6/Mercury; 7440-43-9/Cadmium; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone |
| Comments/Corrections | |
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