Document Detail


The association between body height and coronary heart disease among Finnish twins and singletons.
MedLine Citation:
PMID:  12690014     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: An inverse association between body height and the incidence of coronary heart disease (CHD) has been observed. However, the mechanisms behind this association are still largely unknown. We will examine the role of genetic and familial factors behind the association in a large twin data set. DESIGN AND SETTING: The data were derived from the Finnish Twin cohort including 2438 singletons, 4073 monozygotic (MZ) twins, and 9202 dizygotic (DZ) twins aged 25-69 years at baseline in 1976. Incident CHD cases were derived from hospital discharge data and cause of death data between 1977 and 1995. Cox regression analysis and conditional logistic regression analysis were used. RESULTS: In population-level analyses no differences in the general risk of CHD between zygosity groups were found. The association between body height and CHD was similar between sexes and zygosity groups. When men and women in all zygosity groups were studied together an increased risk of CHD was found only among the shortest quartile (hazard ratio [HR] = 1.34, 95% CI: 1.14-1.57). Among the twin pairs discordant for CHD a suggestive increased risk for the shorter twin was seen among DZ twins (odds ratio [OR] = 1.19, 95% CI: 0.95-1.48) when men and women were studied together. CONCLUSION: An inverse association between body height and CHD was broadly similar between sexes and twin zygosity groups and was associated with short stature. Among discordant twin pairs we found a weak association among DZ twins but not MZ twins. This may suggest the role of genetic liability behind the association between body height and CHD.
Authors:
Karri Silventoinen; Jaakko Kaprio; Markku Koskenvuo; Eero Lahelma
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Twin Study    
Journal Detail:
Title:  International journal of epidemiology     Volume:  32     ISSN:  0300-5771     ISO Abbreviation:  Int J Epidemiol     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-04-11     Completed Date:  2003-05-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802871     Medline TA:  Int J Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  78-82     Citation Subset:  IM    
Affiliation:
Division of Epidemiology, School of Public Health, University of Minnesota, USA. silventoinen@epi.umn.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Body Height / genetics*
Cohort Studies
Coronary Disease / epidemiology,  genetics*
Diseases in Twins* / epidemiology
Female
Finland / epidemiology
Humans
Incidence
Male
Middle Aged
Odds Ratio
Risk
Twins, Dizygotic
Twins, Monozygotic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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