Document Detail


The association between BsmI polymorphism and bone mineral density in young patients with epilepsy who are taking phenytoin.
MedLine Citation:
PMID:  23281616     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: This study sought to determine the association between BsmI polymorphism and bone mineral density, 25-hydroxyvitamin D, and parathyroid hormone levels in patients with epilepsy.
METHODS: We recruited ambulatory young adults with epilepsy who were taking phenytoin. Data regarding demographics, basic laboratory studies, history of clinical epilepsy, parathyroid hormone, and vitamin D levels, as well as BsmI polymorphism of the vitamin D receptor (VDR) gene, were obtained. The bone mineral density (BMD) of the lumbar spine and left femur were measured using dual-energy x-ray absorptiometry.
KEY FINDINGS: Ninety-four patients were included in the study. BsmI polymorphism had a statistically significant lower T-score of the lumbar spine and left femoral neck than patients with wild-type VDR gene (p < 0.01 and p < 0.01, respectively). In addition, patients with BsmI polymorphism had a statistically significant lower z-score of the lumbar spine and left femoral neck than patients with wild-type VDR gene (p < 0.01 and p < 0.01, respectively). The 25-hydroxyvitamin D level in patients with wild-type genes was higher than in epileptic patients with BsmI polymorphism (p < 0.01 and p < 0.01, respectively). Parathyroid hormone level in patients with wild-type VDR gene or patients having BsmI polymorphism was not correlated with BMD at either site.
SIGNIFICANCE:   In patients with epilepsy taking phenytoin, having BsmI polymorphism was associated with lower BMD.
Authors:
Kanitpong Phabphal; Alan Geater; Kitti Limapichart; Pornchai Sathirapanya; Suwanna Setthawatcharawanich; Natthawan Witeerungrot; Natawan Thammakumpee; Ratana Leelawattana
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-02
Journal Detail:
Title:  Epilepsia     Volume:  54     ISSN:  1528-1167     ISO Abbreviation:  Epilepsia     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-06     Completed Date:  2013-04-02     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  249-55     Citation Subset:  IM    
Copyright Information:
Wiley Periodicals, Inc. © 2012 International League Against Epilepsy.
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MeSH Terms
Descriptor/Qualifier:
25-Hydroxyvitamin D 2 / blood
Absorptiometry, Photon
Adolescent
Adult
Anticonvulsants / adverse effects*,  therapeutic use
Bone Density / drug effects*,  genetics*
Calcium / blood
Cross-Sectional Studies
DNA / genetics
Demography
Deoxyribonucleases, Type II Site-Specific / genetics*
Epilepsy / complications*,  drug therapy,  genetics*
Female
Genotype
Humans
Male
Middle Aged
Parathyroid Hormone / blood
Phenytoin / adverse effects*,  therapeutic use
Polymorphism, Genetic / genetics*
Real-Time Polymerase Chain Reaction
Receptors, Calcitriol / genetics
Spectrophotometry, Ultraviolet
Young Adult
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0/Parathyroid Hormone; 0/Receptors, Calcitriol; 21343-40-8/25-Hydroxyvitamin D 2; 6158TKW0C5/Phenytoin; 9007-49-2/DNA; EC 3.1.21.-/endodeoxyribonuclease BsmI; EC 3.1.21.4/Deoxyribonucleases, Type II Site-Specific; SY7Q814VUP/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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