Document Detail


The association of beta-fibrinogen 455 G/A gene polymorphism with left atrial thrombus and severe spontaneous echo contrast in atrial fibrillation.
MedLine Citation:
PMID:  20538554     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The role of coagulation parameters left atrial thrombus formation in atrial fibrillation has not been investigated before. We aimed to investigate the association between the beta-fibrinogen gene polymorphism or glycoprotein IIIa gene polymorphism and presence of left atrial (LA) thrombus or spontaneous echo contrast (SEC) in patients with atrial fibrillation (AF). METHODS: Forty-seven patients with AF, in whom transesophageal echocardiography was performed, were included to this cross-sectional observational study. Patients were divided in two groups; those with LA thrombus (n=24) were assigned to group 1 and those without thrombus in group 2 (n=23). DNA analysis was conducted to determine gene polymorphism in all patients. Mann-Whitney U test or Chi-square tests were used for statistical analysis. RESULTS: There were no significant differences between groups regarding to demographic and clinical characteristics. The frequency of beta-fibrinogen 455 G/A polymorphism was higher (37.5%) in group 1 as compared to group 2 (15.1%) but it did not reach statistical difference (p=0.23). When we added patients with severe SEC in the study group (patients with severe SEC and/or thrombus n=27) the difference (44.40%-10%) reached the statistical difference (p=0.01). Glycoprotein IIIa Pl A1/A2 polymorphism was not different between groups with (p=0.82) or without SEC (p=0.73). CONCLUSION: In patients with atrial fibrillation, beta-fibrinogen 455 G/A gene polymorphism is associated with the presence of left atrial thrombus and severe SEC. Beta-fibrinogen 455 G/A gene polymorphism may be a promising marker for the prediction of thromboembolism risk in patients with atrial fibrillation.
Authors:
Volkan Bozdemir; Onder Kirimli; Bahri Akdeniz; Ayfer Ulgenalp; Abdurrahman Aslan; Veli Kala; Erdem Ozel; Omer Senarslan; Ozer Badak; Nezihi Bariş; Sema Güneri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology     Volume:  10     ISSN:  1308-0032     ISO Abbreviation:  Anadolu Kardiyol Derg     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-11     Completed Date:  2010-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101095069     Medline TA:  Anadolu Kardiyol Derg     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  209-15     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adenine
Aged
Atrial Fibrillation / genetics*,  ultrasonography
Coronary Thrombosis / genetics*
Cross-Sectional Studies
Diabetes Complications / epidemiology
Echocardiography, Transesophageal
Female
Fibrinogen / genetics*
Guanine
Humans
Hypertension / epidemiology
Male
Middle Aged
Mitral Valve Stenosis / ultrasonography
Polymorphism, Single Nucleotide*
Thromboembolism / genetics,  ultrasonography
Chemical
Reg. No./Substance:
0/BBeta fibrinogen; 73-24-5/Adenine; 73-40-5/Guanine; 9001-32-5/Fibrinogen

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