| The association of beta-fibrinogen 455 G/A gene polymorphism with left atrial thrombus and severe spontaneous echo contrast in atrial fibrillation. | |
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MedLine Citation:
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PMID: 20538554 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The role of coagulation parameters left atrial thrombus formation in atrial fibrillation has not been investigated before. We aimed to investigate the association between the beta-fibrinogen gene polymorphism or glycoprotein IIIa gene polymorphism and presence of left atrial (LA) thrombus or spontaneous echo contrast (SEC) in patients with atrial fibrillation (AF). METHODS: Forty-seven patients with AF, in whom transesophageal echocardiography was performed, were included to this cross-sectional observational study. Patients were divided in two groups; those with LA thrombus (n=24) were assigned to group 1 and those without thrombus in group 2 (n=23). DNA analysis was conducted to determine gene polymorphism in all patients. Mann-Whitney U test or Chi-square tests were used for statistical analysis. RESULTS: There were no significant differences between groups regarding to demographic and clinical characteristics. The frequency of beta-fibrinogen 455 G/A polymorphism was higher (37.5%) in group 1 as compared to group 2 (15.1%) but it did not reach statistical difference (p=0.23). When we added patients with severe SEC in the study group (patients with severe SEC and/or thrombus n=27) the difference (44.40%-10%) reached the statistical difference (p=0.01). Glycoprotein IIIa Pl A1/A2 polymorphism was not different between groups with (p=0.82) or without SEC (p=0.73). CONCLUSION: In patients with atrial fibrillation, beta-fibrinogen 455 G/A gene polymorphism is associated with the presence of left atrial thrombus and severe SEC. Beta-fibrinogen 455 G/A gene polymorphism may be a promising marker for the prediction of thromboembolism risk in patients with atrial fibrillation. |
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Authors:
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Volkan Bozdemir; Onder Kirimli; Bahri Akdeniz; Ayfer Ulgenalp; Abdurrahman Aslan; Veli Kala; Erdem Ozel; Omer Senarslan; Ozer Badak; Nezihi Bariş; Sema Güneri |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology Volume: 10 ISSN: 1308-0032 ISO Abbreviation: Anadolu Kardiyol Derg Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-11 Completed Date: 2010-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101095069 Medline TA: Anadolu Kardiyol Derg Country: Turkey |
Other Details:
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Languages: eng Pagination: 209-15 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenine Aged Atrial Fibrillation / genetics*, ultrasonography Coronary Thrombosis / genetics* Cross-Sectional Studies Diabetes Complications / epidemiology Echocardiography, Transesophageal Female Fibrinogen / genetics* Guanine Humans Hypertension / epidemiology Male Middle Aged Mitral Valve Stenosis / ultrasonography Polymorphism, Single Nucleotide* Thromboembolism / genetics, ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/BBeta fibrinogen; 73-24-5/Adenine; 73-40-5/Guanine; 9001-32-5/Fibrinogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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