Document Detail


The association of alanine aminotransferase within the normal and mildly elevated range with lipoproteins and apolipoproteins: the Insulin Resistance Atherosclerosis Study.
MedLine Citation:
PMID:  23344727     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS/HYPOTHESIS: Markers of liver injury, such as alanine aminotransferase (ALT), have been associated with atherogenic lipoprotein changes. We examined the extent to which this association was explained by insulin resistance, adiposity, glucose tolerance and chronic inflammation.
METHODS: In this analysis we included 824 non-diabetic participants (age 40-69 years) in the Insulin Resistance Atherosclerosis Study. No participants reported excessive alcohol intake or treatment with lipid-lowering medications. Lipoproteins and apolipoproteins were measured by conventional methods and lipoprotein heterogeneity by nuclear magnetic resonance (NMR) spectroscopy.
RESULTS: ALT had a positive relationship with triacylglycerols, LDL-to-HDL-cholesterol ratio and apolipoprotein B (ApoB) after adjusting for demographic variables (p < 0.001 for all three relationships). ALT was also associated with the following NMR lipoproteins: positively with large VLDL (p < 0.001), intermediate-density lipoprotein (IDL) (p < 0.001) and small LDL subclass particles (p < 0.001), and VLDL particle size (p < 0.001); and negatively with large LDL subclass particles (p < 0.05) and LDL (p < 0.001) and HDL particle sizes (p < 0.01). ALT remained associated with IDL and small LDL subclass particles and ApoB after adjusting for glucose tolerance, adiposity, directly measured insulin sensitivity and C-reactive protein.
CONCLUSIONS/INTERPRETATION: ALT is associated with a wide range of atherogenic lipoprotein changes, which are partially explained by insulin resistance, adiposity, glucose tolerance and chronic inflammation. Because of the significant variability in the relationship between ALT and liver fat, further studies are needed to assess the extent of the lipoprotein changes using a direct measure of liver fat.
Authors:
C Lorenzo; A J Hanley; M J Rewers; S M Haffner
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural     Date:  2013-01-24
Journal Detail:
Title:  Diabetologia     Volume:  56     ISSN:  1432-0428     ISO Abbreviation:  Diabetologia     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-06     Completed Date:  2013-10-17     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  0006777     Medline TA:  Diabetologia     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  746-57     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adiposity
Adult
Aged
Alanine Transaminase / blood*
Apolipoproteins / blood*
Atherosclerosis / blood*,  ethnology,  metabolism*
Chronic Disease
Female
Glucose Tolerance Test
Humans
Inflammation
Insulin Resistance*
Lipoproteins / blood*
Magnetic Resonance Spectroscopy
Male
Middle Aged
Regression Analysis
Grant Support
ID/Acronym/Agency:
HL-47887/HL/NHLBI NIH HHS; HL-47889/HL/NHLBI NIH HHS; HL-47890/HL/NHLBI NIH HHS; HL-47892/HL/NHLBI NIH HHS; HL-47902/HL/NHLBI NIH HHS; M01 RR01346/RR/NCRR NIH HHS; M01 RR431/RR/NCRR NIH HHS; R01 HL060919/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoproteins; 0/Lipoproteins; EC 2.6.1.2/Alanine Transaminase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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