Document Detail

The association of V249I and T280M fractalkine receptor haplotypes with disease course of multiple sclerosis.
MedLine Citation:
PMID:  22261545     Owner:  NLM     Status:  Publisher    
We investigated the association of CX3CR1 genotypes/haplotypes with MS and performed the prediction analysis of protein sequence variants' effects on CX3CL1/CX3CR1 interaction. We found no association of CX3CR1 with MS susceptibility. Frequency of I(249)T(280) haplotype was significantly lower in SP compared to RR patients (RR>10years, OR=0.30, 95%CI=0.11-0.79, p=0.01; OR=0.53, 95%CI=0.18-1.56, p=0.2, in SP<10years vs. RR>10years). Prediction analysis showed that I249 T280 protein variant would significantly affect CX3CL1/CX3CR1 interaction. Our results suggest that CX3CR1 I(249)T(280) haplotype could have protective effect for switch to SP MS. Further research is warranted to validate and replicate currently observed results.
Ljiljana Stojković; Tamara Djurić; Aleksandra Stanković; Evica Dinčić; Olja Stančić; Nevena Veljković; Dragan Alavantić; Maja Zivković
Related Documents :
20096095 - Genetic and potential non-genetic benefits increase offspring fitness of polyandrous fe...
21609195 - Genetic screening in italian infertile couples undergoing intrauterine insemination and...
18791855 - Intercellular adhesion molecule-1 gene k469e polymorphism and ischemic stroke: a case-c...
15064835 - Molecular study on y chromosome microdeletions in egyptian males with idiopathic infert...
22310945 - A case control study of gene environmental interaction in fetal growth restriction with...
25361775 - A homozygous splice-site mutation in cars2 is associated with progressive myoclonic epi...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-17
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  -     ISSN:  1872-8421     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Laboratory for Radiobiology and Molecular Genetics, "Vinča" Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Meningothelial cells participate in immunological processes in the cerebrospinal fluid.
Next Document:  Associations of moderate alcohol consumption with clinical and MRI measures in multiple sclerosis.