Document Detail


The association of V249I and T280M fractalkine receptor haplotypes with disease course of multiple sclerosis.
MedLine Citation:
PMID:  22261545     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We investigated the association of CX3CR1 genotypes/haplotypes with MS and performed the prediction analysis of protein sequence variants' effects on CX3CL1/CX3CR1 interaction. We found no association of CX3CR1 with MS susceptibility. Frequency of I(249)T(280) haplotype was significantly lower in SP compared to RR patients (RR>10years, OR=0.30, 95%CI=0.11-0.79, p=0.01; OR=0.53, 95%CI=0.18-1.56, p=0.2, in SP<10years vs. RR>10years). Prediction analysis showed that I249 T280 protein variant would significantly affect CX3CL1/CX3CR1 interaction. Our results suggest that CX3CR1 I(249)T(280) haplotype could have protective effect for switch to SP MS. Further research is warranted to validate and replicate currently observed results.
Authors:
Ljiljana Stojković; Tamara Djurić; Aleksandra Stanković; Evica Dinčić; Olja Stančić; Nevena Veljković; Dragan Alavantić; Maja Zivković
Related Documents :
20096095 - Genetic and potential non-genetic benefits increase offspring fitness of polyandrous fe...
21609195 - Genetic screening in italian infertile couples undergoing intrauterine insemination and...
18791855 - Intercellular adhesion molecule-1 gene k469e polymorphism and ischemic stroke: a case-c...
15064835 - Molecular study on y chromosome microdeletions in egyptian males with idiopathic infert...
22310945 - A case control study of gene environmental interaction in fetal growth restriction with...
25361775 - A homozygous splice-site mutation in cars2 is associated with progressive myoclonic epi...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-17
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  -     ISSN:  1872-8421     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Affiliation:
Laboratory for Radiobiology and Molecular Genetics, "Vinča" Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Meningothelial cells participate in immunological processes in the cerebrospinal fluid.
Next Document:  Associations of moderate alcohol consumption with clinical and MRI measures in multiple sclerosis.