| The association of HLA-B*27 subtypes with ankylosing spondylitis in Wuhan population of China. | |
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MedLine Citation:
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PMID: 19536542 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to investigate the association of the B27 subtypes with ankylosing spondylitis (AS) in the Wuhan population of China. We selected 317 HLA-B27-positive individuals (145 controls and 172 patients with ankylosing spondylitis). The B27 subtypes were characterized using a PCR-SSP method. Six B27 subtypes were determined: B*2702, 03, 04, 05, 06 and B*13. HLA-B*2704 and HLA-B*2705 were the two high frequency genotypes in controls and patients. Compared with the controls, the AS patients had high frequency of B*2704 (patients 69.2% vs. controls 53.8%) and low frequency of B*2705 (patients 23.8% vs. controls 33.1%). B*2703 was detected in 10 (5.8%) patients and in 13 (8.9%) controls. B*2702, 06 and B*2713 were relatively rare. Our results show that the allele conferring risk to AS in the Wuhan population of China was B*2704 and B*2705. B*2704 is strongly associated with AS. |
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Authors:
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Xiang Liu; Li-Hua Hu; Yi-Rong Li; Feng-Hua Chen; Yong Ning; Qun-Feng Yao |
Publication Detail:
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Type: Journal Article Date: 2009-06-18 |
Journal Detail:
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Title: Rheumatology international Volume: 30 ISSN: 1437-160X ISO Abbreviation: Rheumatol. Int. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-17 Completed Date: 2010-04-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8206885 Medline TA: Rheumatol Int Country: Germany |
Other Details:
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Languages: eng Pagination: 587-90 Citation Subset: IM |
Affiliation:
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Clinical Laboratory Medicine Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Asian Continental Ancestry Group / genetics Case-Control Studies Chi-Square Distribution China / epidemiology DNA Primers Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease HLA-B Antigens / genetics HLA-B27 Antigen / genetics* Humans Male Middle Aged Phenotype Polymerase Chain Reaction / methods Polymorphism, Genetic* Risk Assessment Risk Factors Spondylitis, Ankylosing / ethnology, genetics*, immunology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/HLA-B 2705 antigen; 0/HLA-B Antigens; 0/HLA-B*2704 antigen; 0/HLA-B27 Antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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