Document Detail


The association of HLA-B*27 subtypes with ankylosing spondylitis in Wuhan population of China.
MedLine Citation:
PMID:  19536542     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to investigate the association of the B27 subtypes with ankylosing spondylitis (AS) in the Wuhan population of China. We selected 317 HLA-B27-positive individuals (145 controls and 172 patients with ankylosing spondylitis). The B27 subtypes were characterized using a PCR-SSP method. Six B27 subtypes were determined: B*2702, 03, 04, 05, 06 and B*13. HLA-B*2704 and HLA-B*2705 were the two high frequency genotypes in controls and patients. Compared with the controls, the AS patients had high frequency of B*2704 (patients 69.2% vs. controls 53.8%) and low frequency of B*2705 (patients 23.8% vs. controls 33.1%). B*2703 was detected in 10 (5.8%) patients and in 13 (8.9%) controls. B*2702, 06 and B*2713 were relatively rare. Our results show that the allele conferring risk to AS in the Wuhan population of China was B*2704 and B*2705. B*2704 is strongly associated with AS.
Authors:
Xiang Liu; Li-Hua Hu; Yi-Rong Li; Feng-Hua Chen; Yong Ning; Qun-Feng Yao
Publication Detail:
Type:  Journal Article     Date:  2009-06-18
Journal Detail:
Title:  Rheumatology international     Volume:  30     ISSN:  1437-160X     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-17     Completed Date:  2010-04-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  587-90     Citation Subset:  IM    
Affiliation:
Clinical Laboratory Medicine Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Asian Continental Ancestry Group / genetics
Case-Control Studies
Chi-Square Distribution
China / epidemiology
DNA Primers
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
HLA-B Antigens / genetics
HLA-B27 Antigen / genetics*
Humans
Male
Middle Aged
Phenotype
Polymerase Chain Reaction / methods
Polymorphism, Genetic*
Risk Assessment
Risk Factors
Spondylitis, Ankylosing / ethnology,  genetics*,  immunology
Young Adult
Chemical
Reg. No./Substance:
0/DNA Primers; 0/HLA-B 2705 antigen; 0/HLA-B Antigens; 0/HLA-B*2704 antigen; 0/HLA-B27 Antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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