Document Detail


The association of Apoprotein E polymorphisms with recurrent pregnancy loss.
MedLine Citation:
PMID:  19086990     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PROBLEM: We have previously reported the role of polymorphisms of thrombogenic genes involved in coagulation and fibrinolysis as risk factors for recurrent pregnancy loss. Thrombophilia has been viewed as a multigenic disorder rather than a monogenetic clinical phenotype and Apo E has been shown to play an important role in lipid metabolism in pregnancy. As individuals carrying the E4 allele of the ApoE gene have the highest risk for thrombosis, we evaluated the frequency of the Apo E4 genotype among women suffering from recurrent pregnancy loss. METHOD OF STUDY: Buccal swabs were obtained from 69 women with a history of two or more consecutive spontaneous abortions and 37 women with at least two live births and not more than one miscarriage. DNA was extracted from the buccal swabs and PCR amplification of Apo E2, E3, and E4 was performed. RESULTS: Women experiencing recurrent pregnancy loss had a significantly higher prevalence of Apo E3/4, E4/4 genotypes (21.7%) compared with control women (5.4%) (P = 0.036). CONCLUSION: Apo E4 polymorphism may contribute to the thrombophilic risk factors contributing to recurrent pregnancy loss.
Authors:
Chelsi Goodman; Cyle S Goodman; Jee Hur; R S Jeyendran; Carolyn Coulam
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  61     ISSN:  1600-0897     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-17     Completed Date:  2009-02-04     Revised Date:  2010-01-11    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  34-8     Citation Subset:  IM    
Affiliation:
CARI Reproductive Institute, Chicago, IL, USA.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Habitual / genetics*,  immunology,  metabolism
Adult
Apolipoproteins E / genetics*,  metabolism
Female
Genotype
Humans
Mutation / genetics
Polymorphism, Genetic / genetics*
Pregnancy
Chemical
Reg. No./Substance:
0/Apolipoproteins E
Comments/Corrections
Comment In:
Am J Reprod Immunol. 2010 Jan;63(1):4; author reply 5-6   [PMID:  20059462 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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