| The t(6;9) associated DEK/CAN fusion protein targets a population of long-term repopulating hematopoietic stem cells for leukemogenic transformation. | |
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MedLine Citation:
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PMID: 20827285 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The t(6;9)-positive acute myeloid leukemia (AML) is classified as a separate clinical entity because of its early onset and poor prognosis. The hallmark of t(6;9) AML is the expression of the DEK/CAN fusion protein. The leukemogenic potential of DEK/CAN has been called into question, because it was shown to be unable to block the differentiation of hematopoietic progenitors. We found that DEK/CAN initiated leukemia from a small subpopulation within the hematopoietic stem cell (HSC) population expressing a surface marker pattern of long-term (LT) HSC. The propagation of established DEK/CAN-positive leukemia was not restricted to the LT-HSC population, but occurred even from more mature and heterogeneous cell populations. This finding indicates that in DEK/CAN-induced leukemia, there is a difference between 'leukemia-initiating cells' (L-ICs) and 'leukemia-maintaining cells' (L-MCs). In contrast to the L-IC cells represented by a very rare subpopulation of LT-HSC, the L-MC seem to be represented by a larger and phenotypically heterogeneous cell population. |
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Authors:
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C Oancea; B Rüster; R Henschler; E Puccetti; M Ruthardt |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-09 |
Journal Detail:
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Title: Leukemia Volume: 24 ISSN: 1476-5551 ISO Abbreviation: Leukemia Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-10 Completed Date: 2010-12-22 Revised Date: 2013-03-04 |
Medline Journal Info:
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Nlm Unique ID: 8704895 Medline TA: Leukemia Country: England |
Other Details:
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Languages: eng Pagination: 1910-9 Citation Subset: IM |
Affiliation:
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Department of Hematology, Goethe University, Frankfurt, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, Ly / genetics Cell Differentiation Colony-Forming Units Assay DNA-Binding Proteins / genetics* Female Hematopoietic Stem Cells / cytology*, drug effects, physiology Leukemia, Experimental / genetics Leukemia, Myeloid, Acute / genetics*, pathology Membrane Proteins / genetics Mice Mice, Inbred C57BL Mutagenesis, Site-Directed Nuclear Pore Complex Proteins / genetics Oncogene Proteins / genetics* Open Reading Frames Recombinant Fusion Proteins / pharmacology Splenomegaly / pathology Translocation, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Ly; 0/DEK protein, mouse; 0/DNA-Binding Proteins; 0/Ly6a protein, mouse; 0/Membrane Proteins; 0/Nuclear Pore Complex Proteins; 0/Oncogene Proteins; 0/Recombinant Fusion Proteins |
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