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An assessment of the muscle blood perfusion of extremities that underwent crush injury by using contrast-enhanced ultrasonography: An animal experiment.
MedLine Citation:
PMID:  23064611     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: This research aimed to study the assessment of local muscle microcirculation perfusion of extremities that underwent crush injuries by using contrast-enhanced ultrasonography (CEUS). METHODS: A total of 28 New Zealand rabbits were anesthetized by using intramuscular pentobarbital sodium (30 mg/kg). A balloon cuff device was used to create crush injuries to the left hind leg of each rabbit with a force of 18.6 kPa. CEUS was performed at the 0.5th, 2nd, 6th, 24th, and 72nd hour after the release of the crush pressure. Peak intensity (PI) of the crushed regions was compared with those of the uncrushed regions and before the creation of crush injury. Receiver operating characteristic analysis was used to determine the diagnostic value of PI for the crushed region. RESULTS: During the 72nd hour after the release of the crush pressure, 5 of the 28 rabbits died, and thus, their statistics were eliminated from the experiment. At different time points after the release of the crush pressure, the crushed regions in all 23 survivals showed quick and high enhancement, and their intensities were higher than those of the uncrushed region in the arterial phase. The time-intensity curves of the crushed regions all appeared as rapid lift-gradual drop. PIs were obviously higher in the crushed regions than in the uncrushed regions and than those before the creation of crush injury (p < 0.001). Receiver operating characteristic curves showed that extremity crush injury was diagnosed by using PI value. CONCLUSION: CEUS presents that the microcirculation perfusion of the crushed muscle increased obviously after the release of the crush pressure. PIs evaluated quantitatively the microcirculation perfusion changes. It may suggest a potential alternative for evaluating microcirculation abnormality of the muscle crush injury to the extremities.
Authors:
Faqin Lv; Jie Tang; Yukun Luo; Yu Ban; Rong Wu; Jiangke Tian; Tengfei Yu; Xia Xie; Tanshi Li
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-11
Journal Detail:
Title:  The journal of trauma and acute care surgery     Volume:  -     ISSN:  2163-0763     ISO Abbreviation:  J Trauma Acute Care Surg     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101570622     Medline TA:  J Trauma Acute Care Surg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
From the Departments of Ultrasound (F.L., J.Tang, Y.L., R.W., J.Tian, T.Y., X.X.) and Emergency (Y.B., T.L.), Chinese People's Liberation Army General Hospital, Beijing, China.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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