Document Detail


An assessment of the joint associations of aspirin and statin use with C-reactive protein concentration.
MedLine Citation:
PMID:  18585504     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The use of aspirin alone and statins alone has been shown to reduce markers of inflammation, including C-reactive protein (CRP); however, their combination has been poorly studied.
METHODS: In a cross-sectional analysis of black and white adults > or =45 years old from the REGARDS cohort, the associations of aspirin and statin use with CRP were examined. Individuals requiring nonsteroidal anti-inflammatory drug therapy or those taking aspirin for reasons other than cardioprotection were excluded from analysis. Participants were classified into 1 of 4 groups: aspirin only (n = 3,673), statin only (n = 1,898), both agents (n = 3,008), or neither agent (n = 7,718).
RESULTS: Estimated mean CRP was 2.78 mg/L for subjects taking neither drug, 2.73 mg/L with aspirin only, 2.29 mg/L with statins only, and 2.03 mg/L for subjects taking both agents. The combined use of both agents was associated with an apparent synergistically lower CRP; the mean CRP level among these combined users was 0.21 mg/L lower than that anticipated from additive association related to aspirin and statins alone (P for interaction = .01). Associations were larger among participants reporting a history of cardiovascular disease. In addition, among statin users, the use of aspirin for >5 years compared with < or =5 years was associated with apparent significantly lower CRP concentrations (P = .01).
CONCLUSIONS: The combined use of aspirin and statins was associated with a synergistically lower CRP concentration, especially among participants taking aspirin for >5 years. Given the limitations of this study and the modest associations, randomized controlled trial evidence is needed to confirm the findings.
Authors:
Matt Fisher; Mary Cushman; Volker Knappertz; George Howard
Related Documents :
24431104 - Dendrimer, liposomes, carbon nanotubes and plga nanoparticles: one platform assessment ...
24477774 - Impact of outpatient interventions made at an ambulatory cancer centre oncology pharmac...
24044994 - A polyvalent aptamer system for targeted drug delivery.
6406804 - Analgesic-induced asthma.
16892224 - Macromolecular immunosuppressants.
11040464 - The use of citalopram in resistant cataplexy.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2008-03-06
Journal Detail:
Title:  American heart journal     Volume:  156     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-30     Completed Date:  2008-07-31     Revised Date:  2013-07-31    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  106-11     Citation Subset:  AIM; IM    
Affiliation:
Bayer HealthCare, Morristown, NJ 07962-1910, USA. matt.fisher.b@bayer.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Aspirin / administration & dosage*
C-Reactive Protein / drug effects*,  metabolism
Cardiovascular Diseases / drug therapy,  prevention & control*
Cross-Sectional Studies
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Therapy, Combination
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage*
Inflammation Mediators / blood
Male
Middle Aged
Probability
Prognosis
Reference Values
Risk Factors
Sensitivity and Specificity
Grant Support
ID/Acronym/Agency:
R01 HL080477/HL/NHLBI NIH HHS; U01 NS041588/NS/NINDS NIH HHS; U01 NS041588/NS/NINDS NIH HHS; U01 NS041588-02/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Inflammation Mediators; 50-78-2/Aspirin; 9007-41-4/C-Reactive Protein
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Exercise capacity and biventricular function in adult patients with repaired tetralogy of Fallot.
Next Document:  Prevalence and extent of dyslipidemia and recommended lipid levels in US adults with and without car...