Document Detail


An assessment of the exposure of Americans to perfluorooctane sulfonate: a comparison of estimated intake with values inferred from NHANES data.
MedLine Citation:
PMID:  20145679     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To better understand human exposure to perfluorinated compounds (PFCs), a model that assesses exposure to perfluorooctane sulfonate (PFOS) and its precursors from both an intake and a body burden perspective and combines the two with a simple pharmacokinetic (PK) model is demonstrated. Exposure pathways were modeled under "typical" and "contaminated" scenarios, for young children and adults. A range of intakes was also estimated from serum concentrations of PFOS reported in the National Health and Nutrition Examination Survey (NHANES) using a first-order 1-compartment PK model. Total PFOS intakes (medians summed over all pathways) were estimated as: 160 and 2200 ng/day for adults and 50 and 640 ng/day for children under typical and contaminated scenarios, respectively. Food ingestion appears to be the primary route of exposure in the general population. For children, the contribution from dust ingestion is nearly as great as from food ingestion. Pathway-specific contributions span several orders of magnitude and exhibit considerable overlap. PK modeling suggests central tendency PFOS intakes for adults range between 1.6 and 24.2 ng/kg-bw/day, and the forward-based intake estimates are within this range. The favorable comparison reported between the forward-modeled and the back-calculated range of intake predictions lends validity to the proposed framework.
Authors:
Peter P Egeghy; Matthew Lorber
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-10
Journal Detail:
Title:  Journal of exposure science & environmental epidemiology     Volume:  21     ISSN:  1559-064X     ISO Abbreviation:  J Expo Sci Environ Epidemiol     Publication Date:    2011 Mar-Apr
Date Detail:
Created Date:  2011-02-17     Completed Date:  2011-05-26     Revised Date:  2012-03-26    
Medline Journal Info:
Nlm Unique ID:  101262796     Medline TA:  J Expo Sci Environ Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  150-68     Citation Subset:  IM    
Affiliation:
Office of Research and Development, U.S. Environmental Protection Agency, National Exposure Research Laboratory, 109 TW Alexander Dr. (MD E205-04), Research Triangle Park, North Carolina 27711, USA. geghy.peter@epa.gov
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MeSH Terms
Descriptor/Qualifier:
Adult
Alkanesulfonic Acids / blood*,  pharmacokinetics,  toxicity
Body Burden
Body Weight
Child
Child, Preschool
Environmental Exposure / analysis*
Environmental Pollutants / blood*,  chemistry,  pharmacokinetics
Female
Fluorocarbons / blood*,  pharmacokinetics,  toxicity
Humans
Male
Models, Biological
Nutrition Surveys / methods*
Risk Assessment / methods
Time Factors
Chemical
Reg. No./Substance:
0/Alkanesulfonic Acids; 0/Environmental Pollutants; 0/Fluorocarbons; 1763-23-1/perfluorooctane sulfonic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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