Document Detail


On the assessment of effects of food on the pharmacokinetics of drugs in early development.
MedLine Citation:
PMID:  12015791     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The impact of food on the pharmacokinetics of a drug has important implications in drug development. This commentary is aimed at addressing two key challenges, developability of drugs whose pharmacokinetics are severely influenced by food, and the need for addressing the effects of fruit juice ingredients which modulate metabolic/efflux properties of a compound. Perspectives on the value in predicting food-drug interactions during preclinical development, timing of clinical food-drug interaction studies, and implications of food effects are presented herein.
Authors:
Zhihong Li; Nimish N Vachharajani; Rajesh Krishna
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Biopharmaceutics & drug disposition     Volume:  23     ISSN:  0142-2782     ISO Abbreviation:  Biopharm Drug Dispos     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-23     Completed Date:  2002-07-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7911226     Medline TA:  Biopharm Drug Dispos     Country:  England    
Other Details:
Languages:  eng     Pagination:  165-71     Citation Subset:  IM    
Copyright Information:
Copyright 2002 John Wiley & Sons, Ltd.
Affiliation:
Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aryl Hydrocarbon Hydroxylases*
Beverages
Biological Availability
Citrus
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System / antagonists & inhibitors,  metabolism
Delayed-Action Preparations / pharmacokinetics
Diet
Drug Evaluation, Preclinical / methods*
Food*
Food-Drug Interactions
Humans
Oxidoreductases, N-Demethylating / antagonists & inhibitors,  metabolism
Pharmacokinetics*
Chemical
Reg. No./Substance:
0/Delayed-Action Preparations; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.14.14.1/Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1/Cytochrome P-450 CYP3A; EC 1.5.-/Oxidoreductases, N-Demethylating

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