| On the assessment of effects of food on the pharmacokinetics of drugs in early development. | |
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MedLine Citation:
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PMID: 12015791 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The impact of food on the pharmacokinetics of a drug has important implications in drug development. This commentary is aimed at addressing two key challenges, developability of drugs whose pharmacokinetics are severely influenced by food, and the need for addressing the effects of fruit juice ingredients which modulate metabolic/efflux properties of a compound. Perspectives on the value in predicting food-drug interactions during preclinical development, timing of clinical food-drug interaction studies, and implications of food effects are presented herein. |
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Authors:
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Zhihong Li; Nimish N Vachharajani; Rajesh Krishna |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Biopharmaceutics & drug disposition Volume: 23 ISSN: 0142-2782 ISO Abbreviation: Biopharm Drug Dispos Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-05-23 Completed Date: 2002-07-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7911226 Medline TA: Biopharm Drug Dispos Country: England |
Other Details:
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Languages: eng Pagination: 165-71 Citation Subset: IM |
Copyright Information:
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Copyright 2002 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aryl Hydrocarbon Hydroxylases* Beverages Biological Availability Citrus Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System / antagonists & inhibitors, metabolism Delayed-Action Preparations / pharmacokinetics Diet Drug Evaluation, Preclinical / methods* Food* Food-Drug Interactions Humans Oxidoreductases, N-Demethylating / antagonists & inhibitors, metabolism Pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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0/Delayed-Action Preparations; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.14.14.1/Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1/Cytochrome P-450 CYP3A; EC 1.5.-/Oxidoreductases, N-Demethylating |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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