Document Detail


An assessment of the dietary uptake of di-2-(ethylhexyl) adipate (DEHA) in a limited population study.
MedLine Citation:
PMID:  8132159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The plasticizer di-2-(ethylhexyl) adipate (DEHA), which may be present in food-contact films, can migrate into certain foodstuffs. Results from plasticizer migration studies into food have enabled an indirect estimate of the maximum daily dietary intake of DEHA. A previous study of the metabolism and pharmacokinetics of DEHA in humans identified the urinary metabolite 2-ethylhexanoic acid (EHA) as a useful marker metabolite for assessing DEHA intake. The present study was designed to investigate urinary EHA concentrations following a controlled dose of DEHA presented with food, and to assess the average daily intake of DEHA in a limited population survey. The urinary elimination profile of EHA, following a dose of DEHA in food, showed that in order to extrapolate DEHA intake from EHA measurements, a 24-hr urine sample was required. In the survey the elimination of EHA was determined in 24-hr urine samples in 112 individuals from five different geographical locations in the UK. No restrictions were placed on age or gender. Estimates of daily intake of DEHA show a skewed distribution with a median value of 2.7 mg. This is similar to an estimated maximum daily intake of 8.2 mg/day, derived using an indirect method by the UK Ministry of Agriculture, Fisheries and Food.
Authors:
N J Loftus; B H Woollen; G T Steel; M F Wilks; L Castle
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  32     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-04-19     Completed Date:  1994-04-19     Revised Date:  2013-11-13    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM    
Affiliation:
Zeneca Central Toxicology, Investigative Toxicology Section, Macclesfield, Cheshire, UK.
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MeSH Terms
Descriptor/Qualifier:
Adipates / administration & dosage*,  urine
Adolescent
Adult
Caproates / urine*
Diet*
Female
Food Contamination*
Great Britain
Humans
Male
Chemical
Reg. No./Substance:
0/Adipates; 0/Caproates; 149-57-5/2-ethylhexanoic acid; 2BD76YG9SI/dioctyl adipate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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