Document Detail

An assessment of central-peripheral ventilatory chemoreflex interaction in humans.
MedLine Citation:
PMID:  1626148     Owner:  NLM     Status:  MEDLINE    
The independence of the central and peripheral chemoreflexes has been tested in humans. Acute metabolic acidosis generated by a prior bout of brief, hard exercise was used to stimulate primarily the peripheral chemoreceptors, and respiratory acidosis generated by inhaled CO2 was used to stimulate both central and peripheral chemoreceptors. Seven healthy young men were studied. Ventilation and arterial pH, PCO2 and PO2 were recorded. Peripheral chemoreflex sensitivity to hypoxia during acute metabolic acidosis was repeatedly determined by measuring ventilation in euoxia (PETO2 = 100 Torr) and hypoxia (PETO2 = 50 Torr) as the subject recovered from exercise-induced acidosis. Peripheral chemoreflex sensitivity to hypoxia during CO2 inhalation was repeatedly determined by measuring ventilation in euoxia and hypoxia at two levels of hypercapnia (PETCO2 = 45 Torr and PETCO2 = 50 Torr). The ventilatory sensitivity to hypoxia at matched arterial pH values was not significantly different between conditions of high (CO2 inhalation) and low (metabolic acidosis) central chemoreceptor activity. We therefore conclude that interaction between central and peripheral chemoreflexes was non-significant in all subjects.
I D Clement; D A Bascom; J Conway; K L Dorrington; D F O'Connor; R Painter; D J Paterson; P A Robbins
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration physiology     Volume:  88     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:    1992 Apr-May
Date Detail:
Created Date:  1992-08-11     Completed Date:  1992-08-11     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  87-100     Citation Subset:  IM; S    
University Laboratory of Physiology, Oxford, U.K.
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MeSH Terms
Carbon Dioxide / metabolism
Chemoreceptor Cells / metabolism*
Hydrogen-Ion Concentration
Oxygen / metabolism
Physical Exertion
Respiration / physiology*
Grant Support
//Wellcome Trust
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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