Document Detail

An assessment of the Coulter VCS automated differential counter scatterplots in the recognition of specific acute leukaemia variants.
MedLine Citation:
PMID:  8536414     Owner:  NLM     Status:  MEDLINE    
The Coulter VCS is an automated differential counter, which derives a five-part differential count on the basis of differences in cell volume, high frequency conductivity and light scatter. A printed scatterplot relating volume and scatter is readily obtained. Other instruments which use automated cytochemistry can distinguish between AML and ALL, and between AML variants. It was our impression that the Coulter VCS might also be capable of such distinction on the basis of the scatterplot patterns. We therefore collected scatterplots produced by Coulter VCS analysis of peripheral blood from 63 patients presenting with acute leukaemia. The scatterplots were inspected and six basic patterns identified. The scatterplots were inspected and six basic patterns identified. The scatterplots could be reproducibly sorted into pattern-specific groups without knowledge of the diagnosis. Precise leukaemic diagnoses were made routinely by conventional morphology, cytochemistry and immunophenotyping. A comparison was then made with the scatterplot patterns. The 51 cases of AML produced examples of all six patterns. The nine cases of ALL produced only three patterns. These were shared with cases of AML, and two were also shared with the three cases of acute mixed lineage leukaemia. Thus, three of the six patterns were specific for AML, whereas no pattern was specific for ALL or acute mixed lineage acute leukaemia. One pattern was produced only by the three cases of AML M6, and another was produced only by five of the 25 cases of primitive (M0 and M1) AML.(ABSTRACT TRUNCATED AT 250 WORDS)
A R Pettitt; P Grace; P Chu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and laboratory haematology     Volume:  17     ISSN:  0141-9854     ISO Abbreviation:  Clin Lab Haematol     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1996-02-05     Completed Date:  1996-02-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907061     Medline TA:  Clin Lab Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  125-9     Citation Subset:  IM    
Department of Haematology, Royal Liverpool University Hospital, UK.
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MeSH Terms
Acute Disease
Leukemia / blood,  diagnosis*
Leukocyte Count / instrumentation,  methods*

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