Document Detail

The aryl hydrocarbon receptor, more than a xenobiotic-interacting protein.
MedLine Citation:
PMID:  17412325     Owner:  NLM     Status:  MEDLINE    
The aryl hydrocarbon (dioxin) receptor (AhR) has been studied for several decades largely because of its critical role in xenobiotic-induced toxicity and carcinogenesis. Albeit this is a major issue in basic and clinical research, an increasing number of investigators are turning their efforts to try to understand the physiology of the AhR under normal cellular conditions. This is an exciting area that covers cell proliferation and differentiation, endogenous mechanisms of activation, gene regulation, tumor development and cell motility and migration, among others. In this review, we will attempt to summarize the studies supporting the implication of the AhR in those endogenous cellular processes.
Robert Barouki; Xavier Coumoul; Pedro M Fernandez-Salguero
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-03-30
Journal Detail:
Title:  FEBS letters     Volume:  581     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-27     Completed Date:  2007-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  3608-15     Citation Subset:  IM    
INSERM, UMR-S 747, 75270 Paris Cedex 06, France.
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MeSH Terms
Cell Adhesion
Cell Movement
Cell Proliferation*
Cell Transformation, Neoplastic / metabolism*
Neoplasms / metabolism*,  pathology
Receptors, Aryl Hydrocarbon / genetics,  metabolism,  physiology*
Signal Transduction
Xenobiotics / metabolism*
Reg. No./Substance:
0/Receptors, Aryl Hydrocarbon; 0/Xenobiotics

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