Document Detail


The aryl hydrocarbon receptor: a molecular pathway for the environmental control of the immune response.
MedLine Citation:
PMID:  23190340     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Environmental factors have significant effects on the development of autoimmune diseases. The ligand-activated transcription factor aryl hydrocarbon receptor (AHR) is controlled by endogenous and environmental small molecules. Hence, AHR provides a molecular pathway by which endogenous and environmental signals can influence the immune response and the development of autoimmune diseases. AHR also provides a target for therapeutic intervention in immune-mediated disorders. In this review, we discuss the role of AHR in the regulation of T-cell differentiation and autoimmunity.
Authors:
Francisco J Quintana
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Immunology     Volume:  138     ISSN:  1365-2567     ISO Abbreviation:  Immunology     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-05     Completed Date:  2013-03-28     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  0374672     Medline TA:  Immunology     Country:  England    
Other Details:
Languages:  eng     Pagination:  183-9     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Autoimmune Diseases / immunology,  metabolism
Autoimmunity / immunology*
Humans
Receptors, Aryl Hydrocarbon / immunology,  metabolism*
Signal Transduction*
T-Lymphocytes / immunology,  metabolism
Grant Support
ID/Acronym/Agency:
AI075285/AI/NIAID NIH HHS; AI093903/AI/NIAID NIH HHS; R01 AI093903/AI/NIAID NIH HHS; RG4111A1/RG/CSR NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Aryl Hydrocarbon
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Identifying biases at different spatial and temporal scales of diversification: a case study in the ...
Next Document:  One-Year Clinical and Radiographic Results with a Novel Hydrophilic Titanium Dental Implant.