Document Detail

An artificial myocardium assist system: electrohydraulic ventricular actuation improves myocardial tissue perfusion in goats.
MedLine Citation:
PMID:  15320949     Owner:  NLM     Status:  MEDLINE    
Artificial hearts and ventricular assist devices have been widely used clinically to assist patients with severe heart failure. Unfortunately, direct contact between the device and the patient's blood leads to thromboembolic events, and then the need for anticoagulation and infections contribute significantly to complication and mortality. Compressing the dysfunctional heart from its epicardial surface, a nonblood-contacting method of direct mechanical ventricular actuation could provide ventricular support, pulsatile blood flow, and avoid interactions between blood and the surface of the artificial assistance system. An ElectroHydraulic Artificial Myocardial (EHAM) assist system that might assist heart muscle contraction has been developed. The purpose of this study is to determine the efficiency of the EHAM system in perfusing myocardial tissue in an acute animal experiment. METHOD: Healthy adult goats (n = 8) were used in acute animal experiments. A left lateral thoracotomy was done and the chest was opened through the 4th and 5th rib resection. Hemodynamic parameters were continuously monitored including ECG, aortic blood pressure, left ventricular pressure, and pulmonary artery pressure. Myocardial tissue perfusion was measured by using an Omega flow laser fiber attached on the surface of the heart. RESULTS: All the animals achieved significantly increased blood pressure, pulmonary artery flow, and myocardial tissue perfusion during the EHAM compression compared with the nondriving (pre-assisted) mode. CONCLUSIONS: The EHAM system can effectively improve myocardial tissue perfusion and increase blood pressure thus demonstrating a potential for treating failing cardiac performance.
Qingtian Wang; Tomoyuki Yambe; Yasuyuki Shiraishi; Xudong Duan; Shinichi Nitta; Kouichi Tabayashi; Mitsuo Umezu
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Artificial organs     Volume:  28     ISSN:  0160-564X     ISO Abbreviation:  Artif Organs     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-23     Completed Date:  2004-12-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  853-7     Citation Subset:  IM    
Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai-shi, Japan.
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MeSH Terms
Equipment Design
Heart-Assist Devices*
Myocardial Contraction*
Myocardial Reperfusion / instrumentation*
Ventricular Function* / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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