| Is arrhythmogenicity related to the speed of reperfusion during thrombolysis for myocardial infarction? | |
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MedLine Citation:
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PMID: 7682509 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to relate the number of ventricular arrhythmias (VA) to the normalization time of the ST segment during thrombolysis for acute myocardial infarction. The 24 h Holter recordings, begun on start of intravenous thrombolytic therapy, and the 12-lead electrocardiograms of 41 patients with a patent infarct-related artery according to coronary angiography were analysed. The mean time from onset of chest pain to angiography was 30.5 +/- 3.1 h, < or = 24 h in 59%. The normalization time of the ST segment, assessed by the time of decrease of ST segment elevation from start of Holter recording to normal or steady state was < or = 60 min in 13 patients (group 1), 60 to 180 min in 15 patients (group 2) and > 180 min in 13 patients (group 3). The incidence of VA was similar in all groups, except for ventricular tachycardias (VT) > 15 beats (group 1:69%, group 2:13%, group 3:15%, P = 0.002). The frequency of accelerated idioventricular rhythms (AIVR), early AIVR (< or = 6 h) and of VT was significantly higher in group 1 than in group 3 with a 8-, 30- and 6-fold increase, respectively (back transformed mean). We conclude that the number of VAs is related to the normalization time of the ST segment during reperfusion. This may suggest that faster reflow is more arrhythmogenic. |
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Authors:
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V Gressin; A P Gorgels; Y Louvard; H Lardoux; R H Bigelow |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European heart journal Volume: 14 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 1993 Apr |
Date Detail:
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Created Date: 1993-05-20 Completed Date: 1993-05-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 516-20 Citation Subset: IM |
Affiliation:
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Cardiology Department, Gilles de Corbeil Hospital, Corbeil-Essonnes, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cardiac Complexes, Premature
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diagnosis,
etiology* Electrocardiography Electrocardiography, Ambulatory Female Humans Male Middle Aged Myocardial Infarction / drug therapy* Myocardial Reperfusion / methods Myocardial Reperfusion Injury / etiology* Streptokinase / therapeutic use Tachycardia, Ventricular / diagnosis, etiology* Thrombolytic Therapy / adverse effects* Time Factors Tissue Plasminogen Activator / therapeutic use |
| Chemical | |
Reg. No./Substance:
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EC 3.4.-/Streptokinase; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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