Document Detail

The area postrema and control of arterial blood pressure; absence of hypertension after excision of the area postrema in rats.
MedLine Citation:
PMID:  564038     Owner:  NLM     Status:  MEDLINE    
Acute surgical excision of the area postrema (AP) in the rat failed to affect arterial blood pressure or heart rate. The was no effect on cardiovascular reflex responses during diving or on the heart rate responses to acute decreases or increases of blood pressure caused by bradykinin or angiotensin, respectively. Electrolytic lesions of the AP in acute experiments caused variable damage to the nucleus tractus solitarii (NTS). In these rats large variations in blood pressure occurred. Excision of the AP in a chronic experiment failed to change blood pressure, heart rate, water intake or plasma renin activity. In contrast, bilateral electrolytic lesions of the NTS at the level of the AP caused a severe acute hypertension and completely blocked cardiovascular reflex responses. Hypertension also existed in rats with NTS lesions studied for a longer period of time. There experiments failed to confirm the hypothesis that the AP exerts a tonic inhibitory control of basal blood pressure. Hypertension previously reported after ablation of the AP may be explained by damage to the NTS.
P Zandberg; M Palkovits; W de Jong
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  372     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  1977 Dec 
Date Detail:
Created Date:  1978-03-10     Completed Date:  1978-03-10     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  169-73     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Angiotensins / pharmacology
Blood Pressure*
Bradykinin / pharmacology
Cerebral Ventricles / physiology*,  surgery
Chronic Disease
Heart Rate
Hypertension / physiopathology*
Reg. No./Substance:
0/Angiotensins; 58-82-2/Bradykinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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