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An aqueous extract of Murraya koenigii leaves induces paraoxonase 1 activity in streptozotocin induced diabetic mice.
MedLine Citation:
PMID:  23207871     Owner:  NLM     Status:  Publisher    
Murraya koenigii (Mk) leaves possess a hypoglycemic effect. Activity of paraoxonase 1 (PON1), a HDL-associated antioxidant enzyme, was found to be decreased during hyperglycemia. The present study explored the effect of Murraya koenigii leaves (MkL) on paraoxonase 1 activity in order to control the oxidative stress in diabetes. Hyperglycemia was induced in mice by a single dose of streptozotocin (200 mg kg(-1) body weight). Diabetic mice were treated with the aqueous extract of MkL orally once daily for 15 days. Doses of 75 and 150 mg kg(-1) body weight of the aqueous MkL extract decreased the blood sugar level significantly in a dose dependant manner. MkL administration significantly reduced oxidative stress by decreasing the MDA level and by increasing GSH level, SOD as well as catalase activity. However, PON1 activity was found to be increased after administration of aqueous MkL extract. MkL treatment also possesses a hypolipidemic effect as inferred from the decrease in total cholesterol, triglyceride level and increase in HDL-C concentration. Here we conclude that after MkL treatment, not only the antioxidant parameters like SOD, CAT, GSH and MDA, but also PON1 may be involved in decreasing the oxidative stress associated with diabetes.
Adrija Saha; Santasree Mazumder
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-4
Journal Detail:
Title:  Food & function     Volume:  -     ISSN:  2042-650X     ISO Abbreviation:  Food Funct     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101549033     Medline TA:  Food Funct     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Biochemistry, University of Calcutta, 35, Ballygunge Circular Road, Kolkata-700019, India.
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