| An aqueous extract of Curcuma longa (turmeric) rhizomes stimulates insulin release and mimics insulin action on tissues involved in glucose homeostasis in vitro. | |
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MedLine Citation:
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PMID: 20734343 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Curcuma longa (turmeric) has been used widely as a spice, particularly in Asian countries. It is also used in the Ayurvedic system of medicine as an antiinflammatory and antimicrobial agent and for numerous other curative properties. The aim of this study was to investigate the effects of an aqueous extract of Curcuma longa (AEC) on tissues involved in glucose homeostasis. The extract was prepared by soaking 100 g of ground turmeric in 1 L of water, which was filtered and stored at -20°C prior to use. Pancreas and muscle tissues of adult mice were cultured in DMEM with 5 or 12 mmol/L glucose and varying doses of extract. The AEC stimulated insulin secretion from mouse pancreatic tissues under both basal and hyperglycaemic conditions, although the maximum effect was only 68% of that of tolbutamide. The AEC induced stepwise stimulation of glucose uptake from abdominal muscle tissues in the presence and absence of insulin, and the combination of AEC and insulin significantly potentiated the glucose uptake into abdominal muscle tissue. However, this effect was attenuated by wortmannin, suggesting that AEC possibly acts via the insulin-mediated glucose uptake pathway. In summary, water soluble compounds of turmeric exhibit insulin releasing and mimicking actions within in vitro tissue culture conditions. Copyright © 2010 John Wiley & Sons, Ltd. |
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Authors:
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Sureshkumar Mohankumar; James R McFarlane |
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Publication Detail:
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Type: Journal Article Date: 2010-08-23 |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 25 ISSN: 1099-1573 ISO Abbreviation: Phytother Res Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 396-401 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 John Wiley & Sons, Ltd. |
Affiliation:
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Centre for Bioactive Discovery, School of Science and Technology, University of New England, Armidale, NSW 2351, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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