| An appropriate indication for the initiation of beta-blocker therapy in dilated cardiomyopathy. | |
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MedLine Citation:
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PMID: 16272814 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although long-term treatment with beta-blockers has been shown to improve morbidity and mortality in dilated cardiomyopathy (DCM), patient responses are heterogeneous. METHODS: To establish the appropriate indication for the initiation of beta-blocker therapy, we retrospectively analyzed 38 DCM patients treated with beta-blockers (metoprolol or carvedilol) and examined differences in baseline profiles between patients who could continue the therapy (responders) and those who could not (non-responders). RESULTS: In 13 non-responders, the duration from onset of symptoms to beta-blocker initiation was longer (p < 0.05), systolic blood pressure was lower (p < 0.001), serum sodium concentration was lower (p < 0.05), left ventricular posterior wall thickness was thinner (p < 0.05), left ventricular end-diastolic pressure was higher (p < 0.05) and left ventricular wall stress was lower (p < 0.05) than in 25 responders. In 19 patients receiving carvedilol, 5 non-responders showed higher levels of human atrial natriuretic peptide (p < 0.05) and brain natriuretic peptide (p < 0.01) than 13 responders. Discriminant analysis with a linear discriminant function showed the following equation predicted response to beta-blocker therapy: h = 0.004 x systolic blood pressure - 0.002 x brain natriuretic peptide + 0.667 (R2 = 0.67, p < 0.001). The probability of predicting the response was 94.1% with h > or = 0.5. CONCLUSION: We conclude that h > or = 0.5 is the appropriate indication for the initiation of beta-blocker therapy in DCM. |
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Authors:
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Toshifumi Morooka; Teruo Inoue; Norihiko Kotooka; Daisuke Fujimatsu; Aiko Komatsu; Fumi Uchida; Kazuyo Yoshida; Shigemasa Hashimoto; Yutaka Hikichi; Toru Kato; Koichi Node |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2005-11-01 |
Journal Detail:
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Title: Cardiology Volume: 105 ISSN: 0008-6312 ISO Abbreviation: Cardiology Publication Date: 2006 |
Date Detail:
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Created Date: 2005-11-25 Completed Date: 2006-03-02 Revised Date: 2010-03-29 |
Medline Journal Info:
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Nlm Unique ID: 1266406 Medline TA: Cardiology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 61-6 Citation Subset: IM |
Copyright Information:
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Copyright 2006 S. Karger AG, Basel. |
Affiliation:
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Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine, Saga, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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therapeutic use* Adult Aged Atrial Natriuretic Factor / blood Biological Markers / blood Blood Pressure / drug effects Cardiomyopathy, Dilated / blood, drug therapy*, physiopathology Discriminant Analysis Female Humans Male Middle Aged Natriuretic Peptide, Brain / blood Predictive Value of Tests Retrospective Studies Stroke Volume / drug effects Treatment Outcome Ventricular Dysfunction, Left / drug therapy Ventricular Pressure / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain; 85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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