| An approach to the problem of metabolic heterogeneity in brain: ischemia and reflow after ischemia. | |
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MedLine Citation:
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PMID: 3439706 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have proposed that tissue metabolic failure during hypoxia or ischemia is related to the microheterogeneous distribution of tissue oxygen and not to failure of the creatine kinase equilibrium. This theory is based on the concept that sharp oxygen gradients exist in rapidly metabolizing tissue and that shifts in these gradients can place specific cells at risk for metabolic death while relatively adjacent cells escape unharmed; cells that are unharmed meet the steady-state requirements (V less than Vmax), those at risk do not (V greater than Vmax). Though it would seem that confirmation of such a hypothesis would require metabolic delineation at a high resolution, we have shown how 31P MRS provides information supporting this hypothesis. This possible use of MR spectroscopy to define microheterogeneous events suggests further clinical possibilities for this instrument in defining the rate of cell loss and the response to therapeutic interventions. |
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Authors:
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B Chance; J S Leigh; S Nioka; T Sinwell; D Younkin; D S Smith |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 508 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 1987 |
Date Detail:
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Created Date: 1988-04-01 Completed Date: 1988-04-01 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 309-20 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Biophysics, University of Pennsylvania Philadelphia 19104. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / metabolism* Disease Models, Animal Dogs Energy Metabolism* Ischemic Attack, Transient / metabolism* Kinetics Magnetic Resonance Spectroscopy / methods Models, Biological Oxygen Consumption* |
| Grant Support | |
ID/Acronym/Agency:
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HL 31934/HL/NHLBI NIH HHS; NS 22881/NS/NINDS NIH HHS; RR 02305/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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