Document Detail

The approach to the mechanism of calcitonin gene-related peptide-inducing inhibition of food intake.
MedLine Citation:
PMID:  19906139     Owner:  NLM     Status:  In-Process    
The aim of this study was to investigate the anorectic mechanism of calcitonin gene-related peptide (CGRP) in rats. Intraperitoneal injection of CGRP (50 μg/kg) resulted in decline (p < 0.05) in the food intake of rats at 0.5, 1, 2 and 4 h in comparison with saline control. Compared with saline-treated group, the levels of hypothalamic 3',5'-cyclic adenosine monophosphate (cAMP) and plasma glucagon were increased (p < 0.05) in CGRP-treated group, but insulin level was decreased (p < 0.05). No significant changes (p > 0.05) in the plasma leptin were observed between two treatment groups. Calcitonin gene-related peptide injection down regulated (p < 0.05) both neuropeptide Y (NPY) and melanin-concentrating hormone (MCH) genes at mRNA levels, but up regulated (p < 0.05) the expression of cholecystokinin (CCK) gene. The correlations analysis showed that food intake was negatively correlated (p < 0.05) with CCK mRNA, cAMP and glucagon levels. Moreover, there existed negative correlations (p < 0.05) between MCH mRNA and glucagon levels, and positive correlations (p < 0.05) between insulin and leptin levels. The results showed that cAMP acting as the second messenger may play a vital role in the anorectic effects of CGRP. Calcitonin gene-related peptide could stimulate anorexigenic neuropeptides (i.e. CCK) and/or inhibit orexigenic neuropeptides (i.e. NPY and MCH) expression, and ultimately suppressed food intake that was functionally coupled to cAMP/PKA pathway activation.
J-Y Sun; M-Y Jing; J-F Wang; X-Y Weng
Related Documents :
18644459 - Association of cocaine- and amphetamine-regulated transcript (cart) messenger rna level...
16183909 - Hormonal regulation of food intake.
7647769 - Neuropeptide y (npy) may integrate responses of hypothalamic feeding systems and the hy...
10837809 - Nicotine administration enhances npy expression in the rat hypothalamus.
18782479 - Duck cerebellum participates in regulation of food intake via the neurotransmitters ser...
10657509 - Introduction to the reviews on peptides and the control of food intake and body weight.
20163509 - Comparison of a food frequency questionnaire with an online dietary assessment tool for...
10798209 - Diet-associated risks of disease and self-reported food consumption: how shall we treat...
12442849 - The politics of obesity: seven steps to government action.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of animal physiology and animal nutrition     Volume:  94     ISSN:  1439-0396     ISO Abbreviation:  J Anim Physiol Anim Nutr (Berl)     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-11-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101126979     Medline TA:  J Anim Physiol Anim Nutr (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  552-60     Citation Subset:  IM    
Copyright Information:
© 2009 Blackwell Verlag GmbH.
The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Science, Zhejiang University, Hangzhou, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of different dietary phytase activities on the concentration of antioxidants in the liver of...
Next Document:  Regional mRNA expression of key gluconeogenic enzymes in the liver of dairy cows.