Document Detail


An approach to the generation of simple analogues of the antitumour agent spicamycin.
MedLine Citation:
PMID:  14649899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The one-step glycosylation of arylamines in acidic medium is extended to adenine derivatives for the first time, providing a considerable improvement over existing reactions. This method is used to prepare some rhamnospicamycin analogues containing different base moieties. Results suggest that this novel approach will be applicable to a wide range of carbohydrates and arylamines, possibly leading to a combinatorial library of analogues of spicamycin for the better understanding of the modes of action of this antitumour antibiotic family.
Authors:
Stéphane Mons; George W J Fleet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  1     ISSN:  1477-0520     ISO Abbreviation:  Org. Biomol. Chem.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-12-01     Completed Date:  2004-06-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  3685-91     Citation Subset:  IM    
Affiliation:
Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford, UK OX1 3QY.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / chemical synthesis*,  chemistry
Glycosylation
Magnetic Resonance Spectroscopy
Mass Spectrometry
Purine Nucleosides / chemical synthesis*,  chemistry
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Purine Nucleosides; 62362-59-8/septacidin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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