| An approach to the generation of simple analogues of the antitumour agent spicamycin. | |
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MedLine Citation:
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PMID: 14649899 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The one-step glycosylation of arylamines in acidic medium is extended to adenine derivatives for the first time, providing a considerable improvement over existing reactions. This method is used to prepare some rhamnospicamycin analogues containing different base moieties. Results suggest that this novel approach will be applicable to a wide range of carbohydrates and arylamines, possibly leading to a combinatorial library of analogues of spicamycin for the better understanding of the modes of action of this antitumour antibiotic family. |
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Authors:
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Stéphane Mons; George W J Fleet |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Organic & biomolecular chemistry Volume: 1 ISSN: 1477-0520 ISO Abbreviation: Org. Biomol. Chem. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-12-01 Completed Date: 2004-06-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101154995 Medline TA: Org Biomol Chem Country: England |
Other Details:
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Languages: eng Pagination: 3685-91 Citation Subset: IM |
Affiliation:
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Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford, UK OX1 3QY. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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chemical synthesis*,
chemistry Glycosylation Magnetic Resonance Spectroscopy Mass Spectrometry Purine Nucleosides / chemical synthesis*, chemistry |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Purine Nucleosides; 62362-59-8/septacidin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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