| The application of transgenic mice for therapeutic antibody discovery. | |
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MedLine Citation:
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PMID: 22723098 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In 2006, panitumumab, the first fully human antibody generated from transgenic mice, was approved for clinical use by the US Food and Drug Administration (FDA). Since then, a further seven such antibodies have been approved. In this chapter, we discuss how transgenic mice technologies can provide a powerful platform for creating human therapeutic antibodies. |
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Authors:
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E-Chiang Lee; Michael Owen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Methods in molecular biology (Clifton, N.J.) Volume: 901 ISSN: 1940-6029 ISO Abbreviation: Methods Mol. Biol. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-06-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9214969 Medline TA: Methods Mol Biol Country: United States |
Other Details:
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Languages: eng Pagination: 137-48 Citation Subset: IM |
Affiliation:
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Kymab Ltd, Meditrina, Cambridge, UK, E-Chiang.Lee@kymab.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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