Document Detail

The application of the sister chromatid exchange test for evaluation of the novel anthracycline derivatives. Part I.
MedLine Citation:
PMID:  15909928     Owner:  NLM     Status:  MEDLINE    
In the first part of our study, which involved the evaluation of the potential cytogenetic activity of the novel anthracycline derivatives with respect to adriamycin in the sister chromatid exchange (SCE) test, we explored the possibilities of using the test in our laboratory and attempted to determine the range of investigated concentrations. We found that adriamycin at concentrations of 0.05 microg/mL and 0.1 microg/mL leads to a statistically significant increase in SCE versus control (p<0.01). We also found that adriamycin levels exceeding 0.2 microg/mL were toxic and suppressed lymphocyte proliferation.
Jadwiga Marczewska; Elzbieta L Anuszewska; Waldemar Priebe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta poloniae pharmaceutica     Volume:  61 Suppl     ISSN:  0001-6837     ISO Abbreviation:  Acta Pol Pharm     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-05-24     Completed Date:  2005-06-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985167R     Medline TA:  Acta Pol Pharm     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  22-4     Citation Subset:  IM    
Department of Biochemistry and Biopharmaceuticals, National Institute of Public Health, 30/34 Chelmska Str. 00-725 Warsaw, Poland.
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MeSH Terms
Anthracyclines / toxicity*
DNA / drug effects,  genetics
Doxorubicin / toxicity
Lymphocytes / drug effects,  ultrastructure
Mutagens / toxicity*
Sister Chromatid Exchange / drug effects*
Reg. No./Substance:
0/Anthracyclines; 0/Mutagens; 23214-92-8/Doxorubicin; 9007-49-2/DNA

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