Document Detail

The application of photodynamic therapy in the treatment of metastatic endobronchial disease.
MedLine Citation:
PMID:  16671103     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: We utilized photodynamic therapy (PDT) for palliation of metastatic endobronchial tumors employing sensitization with synthetic porphyrin, application of non-thermal light, and endoscopic debridement of necrotic tumor. STUDY DESIGN/MATERIALS AND METHODS: Nine patients with symptomatic endobronchial metastasis from carcinomas of the colon(3), breast(3), kidney(2), and tongue(1) received PDT. RESULTS: After two PDT treatments, patients showed substantial response, which was complete in all but one. One patient had perioperative complications and expired 2 days after developing massive hemoptysis during tumor debridement. Patient survival was 6.38 months (mean) and 4.2 months (median). Most patients died from advanced metastatic disease. One patient with metastasis limited to the airway is still alive 24 months following endobronchial presentation. CONCLUSIONS: PDT ameliorates symptoms of metastatic airway obstruction, is easy to apply, has low morbidity and improves the quality of life.
Cynthia M Magro; Abbas E Abbas; Patrick Ross
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lasers in surgery and medicine     Volume:  38     ISSN:  0196-8092     ISO Abbreviation:  Lasers Surg Med     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-27     Completed Date:  2007-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007168     Medline TA:  Lasers Surg Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  376-83     Citation Subset:  IM    
Copyright Information:
Copyright 2006 Wiley-Liss, Inc.
Department of Pathology, The Ohio State University, Columbus, Ohio 43210, USA.
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MeSH Terms
Airway Obstruction / drug therapy,  etiology
Breast Neoplasms / pathology
Bronchial Neoplasms / drug therapy*,  mortality,  secondary*
Colonic Neoplasms / pathology
Dihematoporphyrin Ether / therapeutic use*
Dyspnea / drug therapy,  etiology
Hemoptysis / drug therapy,  etiology
Kidney Neoplasms / pathology
Middle Aged
Palliative Care
Photosensitizing Agents / therapeutic use*
Tongue Neoplasms / pathology
Reg. No./Substance:
0/Photosensitizing Agents; 97067-70-4/Dihematoporphyrin Ether

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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