Document Detail

The application of perpendicular and forward light scatter to assess nuclear and cellular morphology.
MedLine Citation:
PMID:  6489065     Owner:  NLM     Status:  MEDLINE    
Perpendicular and forward light scatter have been employed in a multiparametric approach to distinguish the various lines of the transplantable Dunning R3327 rat prostatic adenocarcinoma. Perpendicular light scatter has been shown to correlate with nuclear size and shape. The average intensity of forward light scatter and perpendicular light scatter signals was demonstrated to increase as cells became less well-differentiated. The combination of perpendicular and forward light scatter allows for the discrimination of histologically indistinguishable tumors and may therefore be useful to establish a system of grading cancer.
M C Benson; D C McDougal; D S Coffey
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cytometry     Volume:  5     ISSN:  0196-4763     ISO Abbreviation:  Cytometry     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1984-12-19     Completed Date:  1984-12-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8102328     Medline TA:  Cytometry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  515-22     Citation Subset:  IM    
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MeSH Terms
Adenocarcinoma / pathology*
Cell Differentiation
Cell Nucleus / pathology*
Prostatic Neoplasms / pathology*
Scattering, Radiation*
Grant Support

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