Document Detail

The application of nuclear magnetic resonance-based metabonomics to the dominant-submissive rat behavioral model.
MedLine Citation:
PMID:  15766725     Owner:  NLM     Status:  MEDLINE    
Nuclear magnetic resonance (NMR) methods were used to study whether there are differences in the urine content between behaviorally distinct groups of rats: dominant and submissive. The dominant-submissive relationships (DSRs) were established in rat pairs competing for access to the feeder filled with sweetened milk. Dominant rats spend significantly longer amounts of time at the feeder than do their submissive partners. During a 2-week period, rats were tested for the DSR. At the end of the second week, behavioral groups of rats were selected and urine was collected during a 3.5-h time period. Principal component analysis revealed a metabolite from milk sugar, galactose, as a discriminating factor between rats classified as dominant and those classified as submissive. Measurements of galactose showed that the amount present in the urine correlated with the time spent in the feeder zone, thereby supporting the time criterion established for the DSR model.
Gregory C Leo; Gary W Caldwell; Jeffrey Crooke; Ewa Malatynska; Carlos Cotto; Becki Hastings; Jaclyn Scowcroft; Jeffrey Hall; Karina Browne; William Hageman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Analytical biochemistry     Volume:  339     ISSN:  0003-2697     ISO Abbreviation:  Anal. Biochem.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-15     Completed Date:  2005-07-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370535     Medline TA:  Anal Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  174-8     Citation Subset:  IM    
Drug Discovery, Johnson & Johnson Pharmaceutical Research & Development, Spring House, PA 19477-0776, USA.
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MeSH Terms
Galactose / urine*
Magnetic Resonance Spectroscopy*
Milk / chemistry*
Models, Animal*
Rats, Sprague-Dawley
Reg. No./Substance:

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