| The application of generalized regression neural network in the modeling and optimization of aspirin extended release tablets with Eudragit RS PO as matrix substance. | |
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MedLine Citation:
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PMID: 12175738 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this work is to use a generalized regression neural network (GRNN) in the design of extended-release aspirin tablets. As model formulations, 10 kinds of aspirin matrix tablets were prepared. Eudragit RS PO was used as matrix substance. The amount of Eudragit RS PO and compression pressure were selected as causal factors. In-vitro dissolution-time profiles at four different sampling times, as well as coefficients n (release order) and log k (release constant) from the Peppas equation were estimated as release parameters. A set of release parameters and causal factors were used as tutorial data for the GRNN and analyzing using a computer. A GRNN model was constructed. The optimized GRNN model was used for prediction of formulation with desired in vitro drug release. For two tested formulations there was very good agreement between the GRNN predicted and observed in vitro profiles and estimated coefficients. Calculated difference (f(1)) and similarity (f(2)) factors indicate that there is no difference between predicted and experimental observed drug release profiles. This work illustrates the potential for an artificial neural network, GRNN, to assist in development of extended-release dosage forms. This method can be employed to achieve a desired in vitro dissolution profile. |
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Authors:
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Svetlana Ibrić; Milica Jovanović; Zorica Djurić; Jelena Parojcić; Ljiljana Solomun |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of controlled release : official journal of the Controlled Release Society Volume: 82 ISSN: 0168-3659 ISO Abbreviation: J Control Release Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-08-14 Completed Date: 2002-11-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607908 Medline TA: J Control Release Country: Netherlands |
Other Details:
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Languages: eng Pagination: 213-222 Citation Subset: IM |
Affiliation:
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Institute for Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, Vojvode Stepe 450, 11221, Belgrade, Yugoslavia. ibric@beotel.yu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acrylic Resins
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chemistry* Anti-Inflammatory Agents, Non-Steroidal Aspirin / chemistry* Computer Simulation Delayed-Action Preparations / chemistry Drug Compounding* Models, Chemical* Neural Networks (Computer)* Research Design Solubility Tablets |
| Chemical | |
Reg. No./Substance:
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0/Acrylic Resins; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Delayed-Action Preparations; 0/Tablets; 33434-24-1/Eudragit RS; 50-78-2/Aspirin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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