Document Detail

The applicability of the results of streamlined trials to clinical practice.
MedLine Citation:
PMID:  2345834     Owner:  NLM     Status:  MEDLINE    
During recent decades we have seen an encouraging development of trial methodology. Less effort, however, has been devoted to the application of findings of trials to the practice of medicine. We cannot expect results of controlled trials alone to determine standard therapy, for clinical judgements are also required. Both beneficial and adverse effects are often only detectable on the group level. There are generally very few indications that drug effects differ qualitatively in subgroups of patients. It is important not only to prove or disprove effects, but also to find out how to implement a proper therapy for a majority of eligible patients. Four examples from treatment after myocardial infraction show that drug usage may not always be based upon results of clinical trials. The adoption of Swedish guidelines for thrombolytic therapy in acute myocardial infarction is taken as an example of an apparently optimal application of trial results in practice.
L Wilhelmsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Statistics in medicine     Volume:  9     ISSN:  0277-6715     ISO Abbreviation:  Stat Med     Publication Date:    1990 Jan-Feb
Date Detail:
Created Date:  1990-06-29     Completed Date:  1990-06-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8215016     Medline TA:  Stat Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  185-91     Citation Subset:  IM    
Gothenburg University, Department of Medicine, Ostra Hospital, Goteborg, Sweden.
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MeSH Terms
Ethics, Medical
Middle Aged
Myocardial Infarction / drug therapy
Physician's Practice Patterns*
Randomized Controlled Trials as Topic / methods*
Thrombolytic Therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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