| The appearance and significance of phospholipase A2 in lymph draining tuberculin reactions. | |
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MedLine Citation:
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PMID: 7081385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Popliteal and prefemoral lymphatics of sheep were cannulated, and lymph was collected before and during the course of responses to PPD and concanavalin A. Hyperemia-inducing activity (HIA) and phospholipase A2 (PLA2) were released into lymph in response to antigenic stimulation, whereas lymph plasma draining unstimulated lymph nodes had consistently little or no detectable HIA and PLA2 activity. HIA appeared in the lymph efferent to the stimulated node at a time when blood flow to the responding node was enhanced. While the appearance of HIA did not directly correlate with changes in lymphocyte output, lymph protein concentration, or lymph flow rates, there was, however, a statistically significant correlation between HIA and PLA2 levels in lymph plasma, suggesting that extracellular PLA2 may contribute to the vasoactivity in lymph and thereby modulate blood flow to areas of antigenic stimulation. Vasoactive lymph, injected into rabbits, induced hyperemia via an indomethacin-sensitive pathway, since the induction of hyperemia was abrogated by pretreatment of injection sites with indomethacin. The extracellular release of PLA2 in response to inflammatory stimuli may represent an amplification mechanism for the generation of high levels of prostaglandins found in lymph draining stimulated nodes. |
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Authors:
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P Vadas; J B Hay |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of pathology Volume: 107 ISSN: 0002-9440 ISO Abbreviation: Am. J. Pathol. Publication Date: 1982 Jun |
Date Detail:
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Created Date: 1982-07-22 Completed Date: 1982-07-22 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0370502 Medline TA: Am J Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 285-91 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Circulation Capillary Permeability Concanavalin A / pharmacology Female Hyperemia / immunology Hypersensitivity, Delayed / enzymology* Indomethacin / pharmacology Lymph / drug effects, enzymology*, immunology Lymph Nodes / blood supply, drug effects, immunology Phospholipases / biosynthesis* Phospholipases A / biosynthesis* Phospholipases A2 Rabbits Regional Blood Flow Sheep Time Factors |
| Chemical | |
Reg. No./Substance:
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11028-71-0/Concanavalin A; 53-86-1/Indomethacin; EC 3.1.-/Phospholipases; EC 3.1.1.-/Phospholipases A; EC 3.1.1.4/Phospholipases A2 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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