Document Detail

The appearance and significance of phospholipase A2 in lymph draining tuberculin reactions.
MedLine Citation:
PMID:  7081385     Owner:  NLM     Status:  MEDLINE    
Popliteal and prefemoral lymphatics of sheep were cannulated, and lymph was collected before and during the course of responses to PPD and concanavalin A. Hyperemia-inducing activity (HIA) and phospholipase A2 (PLA2) were released into lymph in response to antigenic stimulation, whereas lymph plasma draining unstimulated lymph nodes had consistently little or no detectable HIA and PLA2 activity. HIA appeared in the lymph efferent to the stimulated node at a time when blood flow to the responding node was enhanced. While the appearance of HIA did not directly correlate with changes in lymphocyte output, lymph protein concentration, or lymph flow rates, there was, however, a statistically significant correlation between HIA and PLA2 levels in lymph plasma, suggesting that extracellular PLA2 may contribute to the vasoactivity in lymph and thereby modulate blood flow to areas of antigenic stimulation. Vasoactive lymph, injected into rabbits, induced hyperemia via an indomethacin-sensitive pathway, since the induction of hyperemia was abrogated by pretreatment of injection sites with indomethacin. The extracellular release of PLA2 in response to inflammatory stimuli may represent an amplification mechanism for the generation of high levels of prostaglandins found in lymph draining stimulated nodes.
P Vadas; J B Hay
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of pathology     Volume:  107     ISSN:  0002-9440     ISO Abbreviation:  Am. J. Pathol.     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1982-07-22     Completed Date:  1982-07-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370502     Medline TA:  Am J Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  285-91     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Circulation
Capillary Permeability
Concanavalin A / pharmacology
Hyperemia / immunology
Hypersensitivity, Delayed / enzymology*
Indomethacin / pharmacology
Lymph / drug effects,  enzymology*,  immunology
Lymph Nodes / blood supply,  drug effects,  immunology
Phospholipases / biosynthesis*
Phospholipases A / biosynthesis*
Phospholipases A2
Regional Blood Flow
Time Factors
Reg. No./Substance:
11028-71-0/Concanavalin A; 53-86-1/Indomethacin; EC 3.1.-/Phospholipases; EC 3.1.1.-/Phospholipases A; EC A2

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